In this research, a unique strategy was developed to enhance the output performance of 2D ZnO nanosheets based piezoelectric nanogenerator (PENG). The Br doped 2D ZnO nanosheets were fabricated by facile hydrothermal method on nanoporous anodic aluminum oxide (AAO) template. Along with structural and optical characterization of Br doped 2D ZnO nanosheets, the electrical output performance of Br doped 2D ZnO PENG was demonstrated under external mechanical force. The corresponding output voltage of Br doped 2D ZnO nanosheets PENG reached to 8.82 V at 6HZ, which is 3 times higher than undoped ZnO nanosheets PENG. The output power density of Br doped 2D ZnO nanosheets PENG reached to 38.8962 mu Wcm(-2) at an external load resistanec of about 2 M Omega. The Br doping in ZnO nanosheets significantly increased the sensitivity of PENG for pressure sensing and the flexibility of PENG contribute in the application of position sensing.