화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of the Korean Industrial and Engineering Chemistry, Vol.20, No.4, 386-390, August, 2009
Export Citation
폴리(스티렌-설파디아진) 공중합체를 이용한 항균 나노섬유 제조
Construction of Antibacterial Electrospun Nanofiber from Poly(styrene-co-sulfadiazine) via Electrospinning
황석호†, 안경환, 차희철1, 김정열, 황홍구2, 허완수2, 이상원2
  • 한국생산기술연구원 청정생산기술연구부
  • 1한국생산기술연구원 경기기술지원센터
  • 2숭실대학교 환경 화학공학과
Seok-Ho Hwang†, Kyung-Hwan Ahn, Heechul Cha1, Jeong-Yeol Kim, Hong-Gu Hwang2, Wansoo Huh2, and Sangwon Lee2
  • Green Chemistry & Engineering R&D Department, Korea Institute of Industrial Technology, Chonan 330-825, Korea
  • 1Gyeonggi Technology Service Division, Korea Institute of Industrial Technology, Ansan 426-171, Korea
  • 2Department of Chemical & Environmental Engineering, Soongsil University, Seoul 156-743, Korea
E-mail:
초록
항균효과가 있는 sulfadiazine을 포함하는 아크릴형 단량체를 축합반응으로 합성하였으며, 합성된 아크릴형 단량체와 스티렌 단량체를 함께 라디칼 공중합으로 poly(styrene-co-sulfadiazine)을 합성하였다. 중합체의 중량평균분자량이 27800이었으며, 화학구조와 sulfadiazine과 스티렌 단량체간의 몰비는 핵자기공명분석을 통하여 확인하였다. 이 중합체를 이용하여 15 kV 하에서 전기방사를 수행하여 나노섬유 멤브레인을 제조하였으며, 멤브레인을 구성하고 있는 섬유의 직경은 약 500∼800 nm 크기를 가졌다. 제조된 멤브레인의 항균성을 평가하기 위하여 양성균 S. Aureus와 음성균 E. Coli를 사용하였으며, 균주의 colony의 개수 증감으로 항균성을 평가하였다.
In this study, sulfadiazine acrylamide monomer was synthesized by the reaction of sulfadiazine, known as an antibiotic substance, with acryloyl chloride. The monomer was characterized by 1H-NMR, and 13C-NMR. Using the synthesized sulfadiazine acrylamide monomer and styrene monomer, a copolymer, poly(styrene-co-sulfadiazine), was obtained by the free radical copolymerization and characterized by 1H-NMR, GPC, DSC and TGA. The copolymer nanofibers web has been successfully prepared by electrospinning technique under DMF solution. The diameter of the nanofibers was in the range between 500 and 800 nm. Antibacterial activity of the nanofiber web was evaluated utilizing the colony counting method against Staphylococcus aureus and Escherichia coli.
Keywords:poly(styrene-co-sulfadiazine);electrospinning;antibiotics;nanofiber;sulfadiazine
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