Idn this paper, the benefits of intermediate heat exchangers situated in thermally coupled side-column configurations are examined in the separation of component sets having a curved distillation boundary. The simulation results indicate that by incorporating air intermediate heat exchanger the distillation boundary crossing can be enhanced. In consequence, pure product flows may be achieved with decreased total energy requirement. It is also found that thermally coupled side-column configurations having an intermediate heat exchanger require less energy to carry out the desired separation than do the corresponding conventional direct and indirect column schemes. Regardless of the increased complexity and possibility for multiple steady states, intermediate heat exchangers always improve thermodynamic efficiency and widen the potential for heat integration. This paper complements the study started in Part I [Malinen, I.; Tanskanen. J. Thermally coupled side-column configurations enabling distillation boundary crossing. 1. An Over-view and a solving procedure. Ind. Eng. Chem, Res, 2009, 48, DOI: 10.1021/ie800817n] of this series of papers.