Extraction of mangiferin from Mahkota Dewa (Phaleria macrocarpa) using subcritical water

Wan-Joo Kim; Bambang Veriansyah; Youn-Woo Lee; Jaehoon Kim; Jae-Duck Kim

Journal of Industrial and Engineering Chemistry, Vol.16, No.3, 425-430, May, 2010

DOI10.1016/j.jiec.2009.08.008 Export Citation

Extraction of mangiferin from Mahkota Dewa (Phaleria macrocarpa) using subcritical water

Wan-Joo Kim, Bambang Veriansyah, Youn-Woo Lee¹, Jaehoon Kim^†, and Jae-Duck Kim^†

Supercritical Fluid Research Laboratory, Clean Energy Center, Energy Division, Korea Institute of Science and Technology (KIST), 39-1 Hawolgok-dong, Seongbuk-gu,Seoul 136-791, Republic of Korea
¹School of Chemical and Biological Engineering, Seoul National University, Gwanangro 599, Gwanak-gu, Seoul 151-744, Republic of Korea

E-mail:,

A pharmacological active component, mangiferin, was extracted from Mahkota Dewa using subcritical water extraction. The subcritical water extractions were carried out at temperatures ranging 323-423 K, pressures ranging 0.7-4.0 MPa, and extraction times ranging 1-7 h. Extraction yield of mangiferin was measured using high-performance liquid chromatography (HPLC). The extraction yield was strongly dependent on the temperature while weakly dependent on the extraction pressure. As the extraction temperature increased, the extraction mangiferin yield increased, possibly resulting from the decrease in polarity of subcritical water at higher temperature. At an optimal extraction condition of 373 K, 4.0 MPa and extraction time of 5 h, the extraction yield of mangiferin was 21.7 mg/g. This value was close to the extraction yield with methanol (25.0 mg/g) and higher than those with water (18.6 mg/g) or ethanol (13.2 mg/g) at their boiling points.

Keywords:Subcritical water;Mahkota Dewa;Mangiferin;Extraction

[References]

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Leiro J, Arranz JA, Yanez M, Ubeira FM, Sanmart ML, Orallo F, Int. Immunopharmacol., 4, 763 (2004)
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Brunner G, J. Food Eng., 67, 21 (2005)
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Hao LP, Cao XJ, Hur BK, J. Ind. Eng. Chem., 14(5), 639 (2008)
Jeong HH, Yoo KP, Lim JS, J. Ind. Eng. Chem., 14(1), 77 (2008)
King JW, Srinivas K, J. Supercrit. Fluids, 47(3), 598 (2009)
Akerlof G, J. Am. Chem. Soc., 54, 4125 (1932)
Herrero M, Cifuentes A, Ibanez E, Food Chem., 98, 136 (2006)
Kubatova A, Lagadec AJ, Miller DJ, Hawthorne SB, Flavour Frag. J., 16, 64 (2001)
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Cacace JE, Mazza G, J. Food Eng., 77, 1087 (2006)
Kim WJ, Kim J, Veriansyah B, Kim JD, Lee YW, Oh SG, Tjandrawinata RR, J. Supercrit. Fluids, 48(3), 211 (2009)
Kim WJ, Kim JD, Oh SG, Sep. Sci. Technol., 42(14), 3229 (2007)
Li YJ, Bi KS, Chromatographia., 57, 767 (2003)
Luque de Castro MD, Valcarcel M, Tena MT, Analytical Supercritical Fluid Extraction, Springer-Verlag, Germany (1994)
Wu JY, Lin LD, Chau FT, Ultrason. Sonochem., 8, 347 (2001)
Bjorklund E, Nilsson T, Bowadt S, TrAC Trends Anal. Chem., 19, 434 (2000)
Fernandez DP, Goodwin ARH, Lemmon EW, Sengers J, Williams RC, J. Phys. Chem. Ref. Data., 26, 1125 (1997)
Giddings JC, Myers MN, McLaren L, Keller RA, Science., 162, 67 (1968)
Fedors RF, Polym. Eng. Sci., 14, 147 (1974)
King JW, Friedrich JP, J. Chromatogr., 517, 449 (1990)
Galia A, Argentino A, Scialdone O, Filardo G, J. Supercrit. Fluids, 24(1), 7 (2002)
Poling BE, Prausnitz JM, The Properties of Gases and Liquids, 4th ed., McGraw-Hill, New York (1996)

[Referenced By]

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[1] Harmanto N, Conquering Disease in Unison with Mahkota Dewa, PT. Mahkotadewa Indonesia, North Jakarta, Indonesia (2003)

[2] Gotama IBI, Sugiarto S, Nurhadi M, Inventory of Indonesian Medicinal Plants, Research Units and Development, vol. 5, Ministry of Health, Jakarta, Indonesia, 147 (1999)

[3] Leiro J, Arranz JA, Yanez M, Ubeira FM, Sanmart ML, Orallo F, Int. Immunopharmacol., 4, 763 (2004)

[4] Yoshimi N, Matsunaga K, Katayama M, Yamada Y, Kuno T, Qiao Z, Hara A, Yamahara J, Mori H, Cancer Lett., 163, 163 (2001)

[5] Yang Y, Belghazi M, Lagadec A, Miller DJ, Hawthorne SB, J. Chromatogr. A., 810, 149 (1998)

[6] Sugiwati S, Kardono LBS, Bintang M, J. Appl. Sci., 6, 2312 (2006)

[7] Faried A, Kurnia D, Faried LS, Usman N, Miyazaki T, Kato H, Kuwano H, Int. J. Oncol., 30, 605 (2007)

[8] Lang QY, Wai CM, Talanta., 53, 771 (2001)

[9] Brunner G, J. Food Eng., 67, 21 (2005)

[10] Lee SB, Kim HJ, Jung IH, Hong IK, J. Ind. Eng. Chem., 1(1), 83 (1995)

[11] Hao LP, Cao XJ, Hur BK, J. Ind. Eng. Chem., 14(5), 639 (2008)

[12] Jeong HH, Yoo KP, Lim JS, J. Ind. Eng. Chem., 14(1), 77 (2008)

[13] King JW, Srinivas K, J. Supercrit. Fluids, 47(3), 598 (2009)

[14] Akerlof G, J. Am. Chem. Soc., 54, 4125 (1932)

[15] Herrero M, Cifuentes A, Ibanez E, Food Chem., 98, 136 (2006)

[16] Kubatova A, Lagadec AJ, Miller DJ, Hawthorne SB, Flavour Frag. J., 16, 64 (2001)

[17] Rodrı´guez-Meizoso I, Marin FR, Herrero M, Senorans FJ, Reglero G, Cifuentes A, Iba´n.ez E, J. Pharm. Biomed. Anal., 41, 1560 (2006)

[18] Cacace JE, Mazza G, J. Food Eng., 77, 1087 (2006)

[19] Kim WJ, Kim J, Veriansyah B, Kim JD, Lee YW, Oh SG, Tjandrawinata RR, J. Supercrit. Fluids, 48(3), 211 (2009)

[20] Kim WJ, Kim JD, Oh SG, Sep. Sci. Technol., 42(14), 3229 (2007)

[21] Li YJ, Bi KS, Chromatographia., 57, 767 (2003)

[22] Luque de Castro MD, Valcarcel M, Tena MT, Analytical Supercritical Fluid Extraction, Springer-Verlag, Germany (1994)

[23] Wu JY, Lin LD, Chau FT, Ultrason. Sonochem., 8, 347 (2001)

[24] Bjorklund E, Nilsson T, Bowadt S, TrAC Trends Anal. Chem., 19, 434 (2000)

[25] Fernandez DP, Goodwin ARH, Lemmon EW, Sengers J, Williams RC, J. Phys. Chem. Ref. Data., 26, 1125 (1997)

[26] Giddings JC, Myers MN, McLaren L, Keller RA, Science., 162, 67 (1968)

[27] Fedors RF, Polym. Eng. Sci., 14, 147 (1974)

[28] King JW, Friedrich JP, J. Chromatogr., 517, 449 (1990)

[29] Galia A, Argentino A, Scialdone O, Filardo G, J. Supercrit. Fluids, 24(1), 7 (2002)

[30] Poling BE, Prausnitz JM, The Properties of Gases and Liquids, 4th ed., McGraw-Hill, New York (1996)