| 학회 |
한국고분자학회 |
| 학술대회 |
2020년 가을 (10/05 ~ 10/08, 부산컨벤션센터(BEXCO)) |
| 권호 |
45권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Sustained release characterization of donepezil-loaded PLGA microspheres addition to glycolic acid as a release retardant. |
| 초록 |
Donepezil(DP) is an esterase inhibitor and is widely used in Alzheimer's disease. Donepezil loaded Poly (D,L-lactide-co-glycolide) (PLGA) microsphere has a problem in that the drug is rapidly released at an early stage. The purpose of this study is to find the optimal conditions for the release of donepezil loaded microspheres by adding glycolic acid, one of the salts that can be used as a release retardant. PLGA microspheres were prepared using O/W emulsion solvent evaporation, and were prepared by glycolic acid molar ratio, initial drug content, and polymer type. Quantitative analysis was performed using HPLC, and morphological observation was performed using an optical microscope and SEM. Release behavior was confirmed by an in vitro test. As a result, DP75/GA(0.4)-753H showed high encapsulation efficiency and sustained release behavior. Therefore, it is expected that glycolic acid could be used for the development of PLGA sustained-release microsphere injection. |
| 저자 |
김혜민1, 이주화2, 김보연1, 신병철2, 박정숙2
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| 소속 |
1충남대, 2한국화학(연) |
| 키워드 |
PLGA; microsphere; sustained release DDS; O/W emulsion; Donepezil
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| E-Mail |
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