| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 봄 (04/12 ~ 04/13, 대전컨벤션센터) |
| 권호 |
37권 1호 |
| 발표분야 |
의료용고분자 부문위원회 |
| 제목 |
Anti-tumor effects of anti-VEGF siRNA encapsulated with chitosan nanoparticle in vitro |
| 초록 |
We synthesized LMPR(LMWSC-PEG-RGD) and the physicochemical properties investigated by using 1H-NMR, FT-IR, VEGF-siRNA complex measured Dynamic light scattering and Transmission Electron Microscope (TEM). The transfection cytotoxicity of LMPR also was determined by MTT assay. The LMPR Nanoparticle was investigated to siRNA carrier. We describe the feasibility of using chitosan nanoparticles for successful VEGF-siRNA delivery to finally reduce the VEGF level in PC3 cell in vitro. The results demonstrated that the chitosan carrier not only plays an important role in delivery of siRNA into cells but also protects siRNA from RNase degradation.. This research was supported by Basic Science Reaseach Program through the National Research Foundation of Korea(NRF) funded the Ministry of Education, Science and Technology(2011-0012039) |
| 저자 |
홍락준1, 남정표1, 박준규1, 김원석1, 박성철1, 최창용2, 김명렬1, 나재운1, 장미경1
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| 소속 |
1순천대, 2다이나믹 |
| 키워드 |
LMWSC; anti VEGF; Target delivery; gene; cancer therapy.
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| E-Mail |
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