| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 봄 (04/07 ~ 04/08, 대전컨벤션센터) |
| 권호 |
36권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Targeting of Peptide conjugated Chitosan Nanoparticles as a Gene Carrier for Cancer Therapy |
| 초록 |
Targeted polymeric gene delivery system, LMWSC-PEG-RGD (LMPR), was developed by incorporating the αvβ3 integrin-binding RGD peptide (A dimeric RGD peptide, H-Glu[cyclo(Arg-Gly-Asp-D-Phe-Lys)]2, was recently reported to possess high affinity for αvβ3 integrin, into the cationic polymer, LMWSC (Low molecular weight water soluble chitosan) via a hydrophilic polyethylene glycol (PEG) spacer. We synthesized LMWSC-PEG-RGD conjugate and the physicochemical properties of the LMPR were investigated by using 1H-NMR, Dynamic light scattering and Transmission ElectronMicroscope (TEM). The LMPR Nanoparticle was investigated to gene carrier. |
| 저자 |
홍락준, 박준규, 김원석, 최창용, 나재운, 장미경
|
| 소속 |
순천대 |
| 키워드 |
LMWSC; peptide; Target delivery; gene; cancer therapy.
|
| E-Mail |
|
