| 학회 |
한국공업화학회 |
| 학술대회 |
2011년 가을 (11/02 ~ 11/04, 경원대학교) |
| 권호 |
15권 2호 |
| 발표분야 |
정밀화학 |
| 제목 |
In Vitro Therapeutic Effect of Synthetic Deoxycholic acid conjugated Low molecular Water soluble chitosan for Antimicrobial peptide carrier |
| 초록 |
To develop the carrier of antifungal agent petide (A2) based on Low Molecular Water Soluble Chitosan (LMWSC). LMWSC was chemically modified with Deoxycholic acid (DA) which in one of bile acid as a hydrophobic group. The nanoparticles (LMDA) using DA conjugated LMWSC were characterization using dynamic light scattering(DLS) and transmitance electron microscope (TEM). The loaded A2 as an antimicrobial peptide LMDA nanoparticles (LMDA-A2) were prepared. The release of drug from nanoparticles was slow and showed sustained release characteristics. Furthermore, at a concentration of less than LMDA A2 nanoparticles showed lower antibacterial activity than free A2 at concentrations higher the nanoparticles showed similar antibacterial activity to free A2. The LMDA-A2 could be used as an exellent antifungal peptide carrier. |
| 저자 |
박준규, 김태훈, 남정표, 김원석, 최창용, 장미경, 나재운
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| 소속 |
순천대 |
| 키워드 |
Helicobacter pylori; Antimicrobial peptide; HP(2-20); LMWSC; Deoxycholic acid.
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| E-Mail |
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