| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Self-assembled nanopaticles of hydrophobically-moddified Hyaluronic acid nanoparticles for Anticancer agent Carrier |
| 초록 |
Self-assembled nanopaticles of hydrophobically-moddified Hyaluronic acid nanoparticles for Anticancer agent Carrier Hyaluronic acid is a natural plycosaminoglycan and is used widely in the pharmaceutical field. To developed chitosan based Anticancer agent carrier, Hyaluronic acid were chemically modified with hydrophobic group of Bile acid (Deoxycholic acid and Lithocholic acid). The physicochemical properties of the Bile acid-conjugated HA (HDs, HCLs) were investigated by using 1H-NMR, dynamic light scattering and spectrofluorophotometer. HBs nanoparticles were prepared by dialysis method. Anticancer agent-loaded CBs nanoparticles (HCBs-Aa) were investigated by 1H-NMR, dynamic light scattering measurement. The HBs-Aa was investigated to pharmacentcal application as a Anticancer agent carrier. |
| 저자 |
박준규1, 홍낙준1, 이경재1, 최창용1, 나상권2, 장미경1, 나재운1
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| 소속 |
1순천대, 2다이나믹(주) |
| 키워드 |
Hyaluronic acid; drug delivery; bile acid; nanoparticles
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| E-Mail |
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