The solubility of chlorpheniramine maleate in ethanol, 1-propanol, 1-butanol, benzene, ethyl acetate, ethyl formate, and butyl acetate was measured using a laser technique with the temperature range from 283 K to 333 K and at atmospheric pressure. The solubility of chlorpheniramine maleate in pure solvents increases with temperature and in the following order: alcohol solvents > ester solvents > benzene. The experimental solubility data were correlated with a semiempirical equation.