The solubility Of D-glucose in water as a function of temperature in a mixture of ethanol/water containing (50, 60, 70, and 80) % ethanol was evaluated on the basis of the refraction index at 60 degrees C. The results obtained have shown that the solubility in water presents a linear increase with an increase in temperature, whereas for the solutions containing ethanol/water mixtures, this increase is represented by a second-order polynomial. Because glucose shows considerably high solubility, these data can be used to study the glucose crystallization process in mixtures containing antisolvents.