Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials

Yeon-Chun Yoo; Hak-Yong Kim; Fan-Long Jin; Soo-Jin Park

Macromolecular Research, Vol.21, No.6, 687-692, June, 2013

DOI10.1007/s13233-013-1071-0 Export Citation

Synthesis of poly(glycolide-caprolactone) copolymers for application as bioabsorbable suture materials

Yeon-Chun Yoo, Hak-Yong Kim^†, Fan-Long Jin¹, and Soo-Jin Park^{2, †}

Department of Textile Engineering, Chonbuk National University, Jeonbuk, 560-756, Korea
¹School of Chemical and Materials Engineering, Jilin Institute of Chemical Technology, Jilin City, 132022, P. R. China
²Department of Chemistry, Inha University, Nam-gu, Incheon, 402-751, Korea

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A novel bioabsorbable suture, poly(glycolide caprolactone) (PGLCL) copolymer, was synthesized by second step polymerization. The effect of the reaction parameters on the inherent viscosity of the PGLCL prepolymer was examined. The chemical structure of the copolymer was characterized by 1H nuclear magnetic resonance (NMR) and 13C NMR spectroscopy. The thermal properties of the copolymer were examined by differential scanning calorimetry and thermogravimetric analysis. Both the straight strength and knot strength of the PGLCL copolymer monofilament in vivo decreased significantly with increasing implant time. The organism resolvability tests confirmed that the PGLCL copolymer monofilament suture had been absorbed within 91 days with recovery from the inflammatory response. The biocompatibility tests indicated that all items had passed.

Keywords:poly(glycolide caprolactone);copolymer;suture materials;monofilament;bioabsorbable

[References]

Mark HF, Othmer DF, Overberger CG, Seaborg GT, Encyclopedia of Chemical Technology, John Wiley & Sons, New York, 1983.
Lombardi AV, Berend KR, Adams JB, Semin. Arthro., 22, 179 (2011)
Deakin M, Stubbs D, Bruce W, Goldberg J, Gillies RM, Walsh WR, Arthroscopy, 21, 1447 (2005)
Gruber RP, Chang E, Buchanan E, Clin. Plastic Surg., 37, 231 (2010)
Laufman H, Rubel T, Surg. Gynecol. Obstet., 145, 597 (1977)
Tera H, Aberg C, Acta Chir. Scand., 142, 1 (1976)
Varma S, Lumb WV, Johnson LW, Ferguson HL, Am. J. Vet. Res., 42, 571 (1981)
Nirankari VS, Karesh JW, Richar RD, Am. J. Ophthal., 95, 515 (1983)
Bang HJ, Kim HY, Jin FL, Park SJ, J. Ind. Eng. Chem., 17(4), 805 (2011)
Wang D, Shang SB, Song ZQ, Lee MK, J. Ind. Eng. Chem., 16(1), 152 (2010)
Kim JH, Choung PH, Kim IY, Lim KT, Son HM, Choung YH, Cho CS, Chung JH, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 29, 1725 (2009)
Bianco A, Federico ED, Moscatelli I, Camaioni A, Armentano I, Campagnolo L, Dottori M, Kenny JM, Siracusa G, Gusmano G, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 29, 2063 (2009)
Xu HJ, Jin FL, Park SJ, Bull. Korean Chem. Soc., 30, 2643 (2009)
Zhang J, Xu J, Wang H, Jin W, Li J, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 29, 889 (2009)
Chen JL, Jin FL, Park SJ, Macromol. Res., 18(9), 862 (2010)
Jin FL, Rhee KY, Park SJ, J. Solid State Chem., 184, 3253 (2011)
Wust DM, Meyer DC, Favre P, Gerber C, Arthroscopy, 22, 1146 (2006)
Tomihata K, Suzuki M, Oka T, Ikada Y, Polym. Degrad. Stabil., 59, 13 (1998)
Balch OK, Collier A, DeBault LE, Johnson LL, Arthroscopy, 15, 691 (1999)

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[1] Mark HF, Othmer DF, Overberger CG, Seaborg GT, Encyclopedia of Chemical Technology, John Wiley & Sons, New York, 1983.

[2] Lombardi AV, Berend KR, Adams JB, Semin. Arthro., 22, 179 (2011)

[3] Deakin M, Stubbs D, Bruce W, Goldberg J, Gillies RM, Walsh WR, Arthroscopy, 21, 1447 (2005)

[4] Gruber RP, Chang E, Buchanan E, Clin. Plastic Surg., 37, 231 (2010)

[5] Laufman H, Rubel T, Surg. Gynecol. Obstet., 145, 597 (1977)

[6] Tera H, Aberg C, Acta Chir. Scand., 142, 1 (1976)

[7] Varma S, Lumb WV, Johnson LW, Ferguson HL, Am. J. Vet. Res., 42, 571 (1981)

[8] Nirankari VS, Karesh JW, Richar RD, Am. J. Ophthal., 95, 515 (1983)

[9] Bang HJ, Kim HY, Jin FL, Park SJ, J. Ind. Eng. Chem., 17(4), 805 (2011)

[10] Wang D, Shang SB, Song ZQ, Lee MK, J. Ind. Eng. Chem., 16(1), 152 (2010)

[11] Kim JH, Choung PH, Kim IY, Lim KT, Son HM, Choung YH, Cho CS, Chung JH, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 29, 1725 (2009)

[12] Bianco A, Federico ED, Moscatelli I, Camaioni A, Armentano I, Campagnolo L, Dottori M, Kenny JM, Siracusa G, Gusmano G, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 29, 2063 (2009)

[13] Xu HJ, Jin FL, Park SJ, Bull. Korean Chem. Soc., 30, 2643 (2009)

[14] Zhang J, Xu J, Wang H, Jin W, Li J, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 29, 889 (2009)

[15] Chen JL, Jin FL, Park SJ, Macromol. Res., 18(9), 862 (2010)

[16] Jin FL, Rhee KY, Park SJ, J. Solid State Chem., 184, 3253 (2011)

[17] Wust DM, Meyer DC, Favre P, Gerber C, Arthroscopy, 22, 1146 (2006)

[18] Tomihata K, Suzuki M, Oka T, Ikada Y, Polym. Degrad. Stabil., 59, 13 (1998)

[19] Balch OK, Collier A, DeBault LE, Johnson LL, Arthroscopy, 15, 691 (1999)