Synthesis and characterization of pH and temperature sensitive hydrogel based on poly(N-isopropylacrylamide), poly(ε-caprolactone), methylacrylic acid, and methoxyl poly(ethylene glycol)

Xu Xu; Jia Song; Ke Wang; YingChun Gu; Feng Luo; ZhiYong Qian; Ping Xie; XiaoHai Tang

Macromolecular Research, Vol.21, No.8, 870-877, August, 2013

DOI10.1007/s13233-013-1098-2 Export Citation

Synthesis and characterization of pH and temperature sensitive hydrogel based on poly(N-isopropylacrylamide), poly(ε-caprolactone), methylacrylic acid, and methoxyl poly(ethylene glycol)

Xu Xu, Jia Song, Ke Wang, YingChun Gu¹, Feng Luo, ZhiYong Qian^†, Ping Xie^{2, †}, and XiaoHai Tang³

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, P. R. China
¹Mobiles Station for the Biology Post-Doctors, School of Life Sciences, Sichuan University, Chengdu, 610064, P. R. China
²State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, Chengdu, 610064, P. R. China
³ChongQing Lummy Pharmaceutical Co., Ltd, ChongQing, P. R. China

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In this paper, a novel biodegradable and pH/thermo-sensitive hydrogel based on poly(ε-caprolactone), methoxyl poly(ethylene glycol), methylacrylic acid and N-isopropylacrylamide was prepared by UV-initiated free radical polymerization. The hydrogels were characterized by Fourier transforms infrared ray. The thermal responsibility was investigated with the help of differential scanning calorimetry. Swelling behavior in aqueous medium with different pH value was studied in detail. When the pH value of the aqueous medium was increased from 1.2 to 7.2, the swelling ratio of the hydrogels increased accordingly. The morphology was observed by scanning electron microscopy, and the hydrolytic degradation behavior in different aqueous media (pH 1.2 and pH 7.2) was also investigated in detail. The prepared biodegradable pH/thermo-sensitive hydrogel based on poly(?-caprolactone), methoxyl poly(ethylene glycol), methylacrylic acid and N-isopropylacrylamide hold great promise in the development of a smart drug delivery system.

Keywords:biodegradable;hydrogel;pH/thermo-sensitive;degradation;swelling/deswelling

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[Referenced By]

[1] Tasdelen B, Kayaman-Apohan N, Guven O, Baysal BM, Radiat. Phys. Chem., 69, 303 (2004)

[2] Fundueanu G, Constantin M, Ascenzi P, Biomaterials, 29, 2767 (2008)

[3] Hou Y, Matthews AR, Smitherman AM, Bulick AS, Hahn MS, Hou H, Han A, Grunlan MA, Biomaterials, 29, 3175 (2008)

[4] Chao GT, Qian ZY, Huang MJ, Kan B, Gu YC, Gong CY, Yang JL, Wang K, Dai M, Li XY, Gou ML, Tu MJ, Wei YQ, J. Biomed. Mater. Res., 85, 36 (2008)

[5] Liu CB, Gong CY, Pan YF, Zhang YD, Wang JW, Huang MJ, Wang YS, Wang K, Gou ML, Tu MJ, Wei YQ, Qian ZY, Colloids Surf. A: Physicochem. Eng. Asp., 302, 430 (2007)

[6] Ostroha J, Pong M, Lowman A, Dan N, Biomaterials, 25, 4345 (2004)

[7] Qiu Y, Park K, Adv. Drug Deliv. Rev., 53, 321 (2001)

[8] Hoffman AS, Adv. Drug Deliv. Rev., 54, 3 (2002)

[9] Bajpai SK, Singh S, React. Funct. Polym., 66(4), 431 (2006)

[10] Lin YH, Liang HF, Chung CK, Chen MC, Sung HW, Biomaterials, 26, 2105 (2005)

[11] Inoue T, Chen G, Nakamae K, Hoffmana AS, J. Control. Release, 51, 221 (1998)

[12] Riley T, Stolnik S, Heald CR, Xiong CD, Garnett MC, Illum L, Davis SS, Purkiss SC, Barlow RJ, Gellert PR, Langmuir, 17(11), 3168 (2001)

[13] Huynh DP, Nguyen MK, Pi BS, Kim MS, Chae SY, Lee KC, Kim BS, Kim SW, Lee DS, Biomaterials, 29, 2527 (2008)

[14] Jeong B, Bae YH, Lee DS, Kim SW, Nature, 388(6645), 860 (1997)

[15] Pitarresi G, Casadei MA, Mandracchia D, Paolicelli P, Palumbo FS, Giammona G, J. Control. Release, 119, 328 (2007)

[16] Iemma F, Spizzirri UG, Puoci F, Muzzalupo R, Trombino S, Cassano R, Leta S, Picci N, Int. J. Pharm., 312, 151 (2006)

[17] Torres-Lugo M, Peppas NA, Macromolecules, 32(20), 6646 (1999)

[18] Nho YC, Park SE, Kim HI, Hwang TS, Nucl. Instrum. Methods Phys. Res. Sect. B-Beam Interact. Mater. Atoms, 236, 283 (2005)

[19] Calceti P, Salmaso S, Walker G, Bernkop-Schnurch A, Int. J. Pharm., 22, 315 (2004)

[20] Li XY, Wu WH, Liu WQ, Carbohydr. Polym., 71, 394 (2008)

[21] Shin BC, Kim SS, Ko JK, Jegal J, Lee BM, Eur. Polym. J., 39, 579 (2003)

[22] Yang JM, Yang SJ, Lin HT, Wu TH, Chen HJ, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 28, 150 (2008)

[23] Wang B, Xu XD, Wang ZC, Cheng SX, Zhang XZ, Zhuo RX, Colloids Surf. B: Biointerfaces, 64, 34 (2008)

[24] Kuckling D, Hoffmann J, Plotner M, Ferse D, Kretschmer K, Adler HJP, Arndt KF, Reichelt R, Polymer, 44(16), 4455 (2003)

[25] da Silva R, de Oliveira MG, Polymer, 48(14), 4114 (2007)

[26] Yoo MK, Sung YK, Lee YM, Cho CS, Polymer, 41(15), 5713 (2000)

[27] Chilkoti A, Dreher MR, Meyer DE, Raucher D, Adv. Drug Deliv. Rev., 54, 613 (2002)

[28] Liu Q, Zhu ZY, Yang XM, Chen XL, Song YF, Radiat. Phys. Chem., 76, 707 (2007)

[29] Wang K, Fu SZ, Gu YC, Xu X, Dong PW, Guo G, Zhao X, Wei YQ, Qian ZY, Polym. Degrad. Stabil., 94, 730 (2009)

[30] Nuttelman CR, Henry SM, Anseth KS, Biomaterials, 23, 3617 (2002)

[31] Bell CL, Peppas NA, Biomaterials, 17, 1203 (1996)

[32] Liu WG, Zhang BQ, Lu WW, Li X, Zhu DW, Yao KD, Wang Q, Zhao CR, Wang CD, Biomaterials, 25, 3005 (2004)

[33] Wu XS, Hoffman AS, Yager P, J. Polym. Sci. A: Polym. Chem., 30, 2121 (1992)

[34] Guo BL, Gao QY, Carbohydr. Res., 342, 2416 (2007)