Polyethylene glycol monomethacrylate(PEGM) and dimethyl aminoethyl methacrylate(DMAEMA) were grafted onto chitosan. After crosslinked membranes were prepared using glutaraldehyde with respective graft copolymers produced above, their thermal stability and mechanical properties were investigated. Their initial degradation temperature became higher than that of chitosan and their mechanical properties were improved as the degree of crosslinking increased and they did not become good as the percentage of grafting increased. But water content increased as the percentage of grafting increased and as the degree of crosslinking decreased. For permeability using riboflavin and cyanocobalamine, as model drugs, their solute permeability was able to be controlled through the variation of their water content because the permeation depended entirely upon that. And it was verified that solute permeated through the water region contained in hydrophilic polymer membrane where no interaction between the polymer chains took place.