Dextran을 기초로 한 고분자 Matrix로 부터의 Silver Sulfadiazine의 방출특성

나재운; 박영훈; 김성현; 김선일

Journal of the Korean Industrial and Engineering Chemistry, Vol.7, No.4, 735-742, August, 1996

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Dextran을 기초로 한 고분자 Matrix로 부터의 Silver Sulfadiazine의 방출특성

Release Characteristics of Silver Sulfadiazine from Dextran-based Polymeric Matrices

나재운, 박영훈, 김성현, 김선일

초록

장시간에 걸쳐 약물의 흡수가 일어날 수 있는 고분자 matrix을 개발하고자, 글리세린과 증류수를 혼합 교반 시킨 후, 분자량이 서로 다른 세 종류의 dextran을 각각 첨가하여 용해시켰다. 이 용액에 silver sulfadiazine을 분산시켜 matrix를 제조하였다. 이렇게 제조된 고분자 matrix로부터 약물 방출 양상을 규명하기 위해 인산염 완충용액 중에서 약물의 함유량 변화, dextran의 분자량 변화 및 글리세린의 농도 변화에 영향을 미치는 인자들에 관하여 연구 검토한 바 다음과 같은 결론을 얻었다. 고분자 matrix내의 silver sulfadiazine의 함유량이 증가할수록 약물 방출 지속 시간은 11.2일, 14.0일 및 15.8일로 지연되었다. Dextran의 분자량 변화에 대해서는 약 14.0일로 거의 같은 약물 방출 pattern을 보임으로써 겉보기 방출속도상수 (K)값과의 관계와 일치하는 결과를 얻었다. 그러나 글리세린의 함유량이 증가함에 따라 약물 방출 지속 시간은 각각 18.0일, 17.0일, 14.0일, 13.0일 및 10.0일로 감소하였다.

Polymeric matrices were prepared with dextran and silver sulfadiazine by adding glycerine as a plasticiser. Namely, the release rate of the drug from the polymeric matrix formulations in dissolved phases was determined in a phosphate buffer solution. The results were as follows : The drug release time was delayed as drug loading contents increased, whereas it decreased as the glycerine concentration increased. The drug release time was not changed with varying the molecular weight of the dextran. The apparent release rate constant (k) increased as the composition of silver sulfadiazine and glycerine was increased. But the apparent release rate constant (k) was not changed with increasing molecular weight of the dextran.

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[1] Sidebotham RL, Dextrans. Adv. Carbohydr. Chem. Biochem., 30, 371 (1984)

[2] Pasteur L, Bull. Soc. Chem. Paris, 30 (1961)

[3] Scheubler C, Z. Ver. Dtsch. Zucker-Lnd., 24 (1874)

[4] Hehre EJ, Senti FR, Hellonan NN, J. Biol. Chem., 222, 759 (1956)

[5] Moore JA, "Polymer Science and Technology," 21, 752-755, Plenum (1984)

[6] Takakura Y, Matsumoto S, hashida M, Sezaki H, Cancer Res., 44, 2505 (1984)

[7] Donbrow M, Friedman M, J. Pharm. Sci., 64, 76 (1975)

[8] Gidwani RN, J. Pharm. Sci., 61, 985 (1972)

[9] Keith AD, European Patent, 0,013,606 (1972)

[10] Shah NB, Sheth BB, J. Pharm. Sci., 61, 412 (1972)

[11] Cohen J, Siegal RA, Langer R, J. Pharm. Sci., 73, 1034 (1984)

[12] Higuchi T, J. Pharm. Sci., 50, 874 (1961)

[13] Higuchi T, J. Pharm. Sci., 52, 1145 (1963)

[14] Desai SJ, Simonelli AP, Higuchi WI, J. Pharm. Sci., 54, 1459 (1965)

[15] Lapidus H, Lordi NG, J. Pharm. Sci., 55, 840 (1966)

[16] Desai SJ, Singh P, Simonelli AP, Higuchi WI, J. Pharm. Sci., 55, 1224 (1966)

[17] Singh P, Desai SJ, Simonelli AP, Higuchi WI, J. Pharm. Sci., 56, 1542 (1967)

[18] Lapidus H, Lordi NG, J. Pharm. Sci., 57, 1292 (1968)

[19] Farhadieth B, Borodkin S, Buddenhagen JD, J. Pharm. Sci., 60, 209 (1971)

[20] Crank J, Park GS, "Diffusion in Polymers," Academic Press, New York, 309-335 (1968)

[21] Richards RW, "The Permeability of Polymers to Gases, Vapors, and Liquids," ERDE Tech. Report 135, Washington, D.C. (1973)

[22] Flinch CA, "Chemistry and Technology of Water-Soluble Polymer," Chap. 17, Plenum (1983)

[23] Kim CK, Jo ES, Yakhak Hoeji, 31, 25 (1987)

[24] Martin A, Swarbrick J, "Physical Pharmacy," 22-29, Lea and Febiger, Philadelphia (1984)