Functionality of Polypeptide by Induction of Specific Tertiary Structure

Imanishi Y; Kimura S

Korea Polymer Journal, Vol.4, No.2, 154-159, October, 1996

Two different approaches for arranging functional groups regularly in space are presented. One way is based on the covalently bonding chemistry as exemplified by proteins. Here, a helix-bundle structure was elaborately prepared by connecting two or three helices to a template molecule. The peptide carrying three helices in the molecule formed ion channel at lower concentration than the peptides of the helical part alone or carrying two helices in the molecule. The other way is based on the self-assembling system. The amphiphiles carrying a chromophore-containing amino acid formed a bilayer membrane in water. The membrane showed efficient photo-energy migration between chromophores and effectively reduced cytochrome c by photo-irradiation.

[References]

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[1] Mutter M, Vuilleumier S, Angew. Chem.-Int. Edit., 28, 535 (1989)

[2] Kunitake T, Okahata Y, J. Am. Chem. Soc., 99, 3860 (1977)

[3] Taku K, Sasaki H, Kimura S, Imanishi Y, Amino Acids, 7, 311 (1994)

[4] Montal M, Muller P, Proc. Natl. Acad. Sci. U.S.A., 69, 3561 (1972)

[5] Olson F, Hunt CA, Szoka FC, Vail WJ, Papahadjopoulos D, Biochim. Biophys. Acta, 557, 9 (1979)

[6] Imanishi Y, Kimura S, The Handbook of Nunmedical Applications of Liposomes, Vol. II, Models for Biological Phenomena, Y. Barenholz & D.D. Lasic, Eds., CRC Press, Inc., Boca Raton, Vol. 2, pp. 187-198 (1996)

[7] Menestrina G, Voges KP, Jung G, Boheim G, J. Membr. Biol., 93, 111 (1986)

[8] Otoda K, Kimura S, Imanishi Y, Biochim. Biophys. Acta, 1150, 1 (1993)

[9] Otoda K, Kitagawa Y, kimura S, Imanishi Y, Biopolymers, 33, 1337 (1993)

[10] Gibson NJ, Gassim JY, Biochemistry, 28, 2134 (1989)

[11] Yokoyama M, Tamamura T, Atsumi M, Yoshimura M, Shirota Y, Mikawa H, Macromolecules, 8, 101 (1975)

[12] Okuyama K, Soboi Y, Tijima N, Hirabayashi K, Kunitake T, Tajiyama T, Bull. Chem. Soc. Jpn., 61, 1485 (1988)

[13] Tsuchida A, Sakai W, Nakano M, Yamamoto M, J. Phys. Chem., 96, 8855 (1992)

[14] Tsuchida A, Sakai W, Nakano M, Yoshida M, Yamamoto M, Chem. Phys. Lett., 188, 254 (1992)

[15] Nakamura H, Fujii H, Sakaguchi H, Matsuo T, Nakashima N, Yoshihata K, Ikeda T, Tazuke S, J. Phys. Chem., 92, 6151 (1988)

[16] Itaya A, Yamada T, Masuhara H, Phys. Lett., 145, 174 (1990)