Characterization and Stability of Core-Crosslinkable MePEG/PDLLA Block Copolymer Micelle by Light Scattering Technique (II)

Ji-Heung Kim; Kazunori Kataoka

Journal of Industrial and Engineering Chemistry, Vol.5, No.2, 133-138, June, 1999

Ji-Heung Kim^†, and Kazunori Kataoka¹

Department of Chemical Engineering, Sungkyunkwan University, Kyonggi 440-746, Korea
¹Department of Materials Science, Graduate School of Engineering, the University of Tokyo, Tokyo 113-8656, Japan

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MePEG/PDLLA block copolymer micelle containing methacryloyl functional end was prepared and core-stabilization was achieved via chemical and photochemical polymerization of methacryloyl group within the micelle core. The characterization of micelle solution and stability study of the core-polymerized one were carried out by using both dynamic and static light scattering technique.

Keywords:MePEG/PDLLA;block copolymer;micelle;core-stabilization;light scattering

[References]

Malmsten M, Lindman B, Macromolecules, 25, 5440 (1992)
Kataoka K, Kwon GS, Yokoyama M, Okano T, Sakurai Y, J. Control. Release, 24, 119 (1993)
Kwon GS, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K, Langmuir, 9, 945 (1993)
Yokoyama M, Kwon GS, Okano T, Sakurai Y, Sato T, Kataoka K, Bioconfugate Chem., 3, 295 (1992)
Yokoyama M, Crit. Rev. Ther. Drug Carrier Systems, 9, 213 (1992)
Peracchia MT, Gref R, Minamitake Y, Domb A, Lotan N, Langer R, J. Control. Release, 46, 223 (1997)
Hagan SA, Coombes AG, Garnett MC, Dunn SE, Davis MC, Illum L, Davis SS, Harding SE, Purkiss S, Gellert PR, Langmuir, 12(9), 2153 (1996)
Bazile D, Prudhomme C, Bassoullet MT, Marlard M, Spenlehauer G, Veillard M, J. Pharm. Sci., 84(4), 493 (1995)
Piskin E, Kaitian X, Denkbas EB, Kucukyavuz Z, J. Biomater. Sci.-Polym. Ed., 7(4), 359 (1995)
Zhang X, Jackson JK, Burt HM, Int. J. Pharm., 132, 195 (1996)
Yokoyama M, Okano T, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K, Cancer Res., 51, 3229 (1991)
Tuzar Z, Webber SE, Prochazka K, Ramireddy C, Munk P, Polym. Prepr. ACS Div. Polym. Chem., 32, 525 (1991)
Kim JH, Iijima M, Nagasaki Y, Kataoka K, Polym. Prepr. ACS Div. Polym. Chem., 39, 130 (1998)
Kim JH, Nagasaki Y, Kataoka K, J. Ind. Eng. Chem., 4(3), 244 (1998)
Xu R, Winnik MA, Hallett FR, Riess G, Croucher MD, Macromolecules, 24, 87 (1991)

[Related Articles]

[1] Malmsten M, Lindman B, Macromolecules, 25, 5440 (1992)

[2] Kataoka K, Kwon GS, Yokoyama M, Okano T, Sakurai Y, J. Control. Release, 24, 119 (1993)

[3] Kwon GS, Naito M, Yokoyama M, Okano T, Sakurai Y, Kataoka K, Langmuir, 9, 945 (1993)

[4] Yokoyama M, Kwon GS, Okano T, Sakurai Y, Sato T, Kataoka K, Bioconfugate Chem., 3, 295 (1992)

[5] Yokoyama M, Crit. Rev. Ther. Drug Carrier Systems, 9, 213 (1992)

[6] Peracchia MT, Gref R, Minamitake Y, Domb A, Lotan N, Langer R, J. Control. Release, 46, 223 (1997)

[7] Hagan SA, Coombes AG, Garnett MC, Dunn SE, Davis MC, Illum L, Davis SS, Harding SE, Purkiss S, Gellert PR, Langmuir, 12(9), 2153 (1996)

[8] Bazile D, Prudhomme C, Bassoullet MT, Marlard M, Spenlehauer G, Veillard M, J. Pharm. Sci., 84(4), 493 (1995)

[9] Piskin E, Kaitian X, Denkbas EB, Kucukyavuz Z, J. Biomater. Sci.-Polym. Ed., 7(4), 359 (1995)

[10] Zhang X, Jackson JK, Burt HM, Int. J. Pharm., 132, 195 (1996)

[11] Yokoyama M, Okano T, Sakurai Y, Ekimoto H, Shibazaki C, Kataoka K, Cancer Res., 51, 3229 (1991)

[12] Tuzar Z, Webber SE, Prochazka K, Ramireddy C, Munk P, Polym. Prepr. ACS Div. Polym. Chem., 32, 525 (1991)

[13] Kim JH, Iijima M, Nagasaki Y, Kataoka K, Polym. Prepr. ACS Div. Polym. Chem., 39, 130 (1998)

[14] Kim JH, Nagasaki Y, Kataoka K, J. Ind. Eng. Chem., 4(3), 244 (1998)

[15] Xu R, Winnik MA, Hallett FR, Riess G, Croucher MD, Macromolecules, 24, 87 (1991)