수정된 유사체액 내에서 티타늄에 생성된 아파타이트의 고분해능 전자현미경에 의한 분석

김현욱; 김우정; 이갑호; 홍순익; Hyun-Ook Kim; Woo-Jeong Kim; Kap-Ho Lee; Sun-Ig Hon

Korean Journal of Materials Research, Vol.17, No.8, 408-413, August, 2007

DOI10.3740/MRSK.2007.17.8.408 Export Citation

수정된 유사체액 내에서 티타늄에 생성된 아파타이트의 고분해능 전자현미경에 의한 분석

HRTEM Analysis of Apatite Formed on Bioactive Titanium in Modified-SBF

김현욱, 김우정, 이갑호^†, 홍순익

충남대학교 공과대학 나노공학부

Hyun-Ook Kim, Woo-Jeong Kim, Kap-Ho Lee^†, and Sun-Ig Hon

Division of Nano Technology, Chungnam National University, Daejeon 305-7641, South Korea

E-mail:

Process of the hydroxyapapite(HA) precipitation on bioactive titanium metal prepared by NaOH in a modified-simulated body fluid(mSBF) was investigated by high resolution transmission electron microscope (HRTEM) attached with energy dispersive X-ray spectrometer(EDX). The amorphous titanate phase on titanium surface is form by NaOH treatment and an amorphous titanate incorporated calcium and phosphate ions in the liquid to form an amorphous calcium phosphate. With increasing of soaking time in the liquid, the HA particles are observed in amorphous calcium phosphate phase with a Ca/P atomic ratio of I.30. The octacalcium phosphate (OCP) structure is not detected in HRTEM image and electron diffraction pattern. After a long soaking time, the HA particles grow as needle-like shape on titanium surface and a large particle-like aggregates of needle-like substance were observed to form on titanium surface within needle-like shape. A long axis of needle parallels to c-direction of the hexagonal HA structure.

Keywords:titanium metal;hydroxyapatite(HA);modified-simulated body fluid(mSBF);high resolution transmission electron microscopy (HRTEM) . energy dispersive X-ray spectrometry(EDX)

[References]

Kim HM, Miyaji F, Kokubo T, Nakamura T, J. Biomed. Mater. Res., 32, 409 (1996)
Kokubo T, Miyaji F, Kim HM, Nakamura T, J. Am. Ceram. Soc., 79, 1127 (1996)
Ohtsuki C, Idia H, Hayakawa S, Osaka A, J . Biomed. Mater. Res., 35, 39 (1997)
Kaneko S, Tsuru K, Hayakawa S, Takemoto S, Ohtsuki C, Ozaki T, Inoue H, Biomaterials, 22, 875 (2001)
Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yammamuro T, J. Biomed. Mater. Res., 24, 721 (1990)
De Groot K, Geesink RGf, Klein CPAT, Serekian P, J Biomed Mater Res., 21, 1375 (1987)
Klein CAPT, Patka P, CAPT, Van der Lubbe HBM, Wolke JGC, De Grook K, J. Biomed. Mater. Res., 25, 53 (1991)
Duchyene P, Van Earmodonck W, Heughbaert JC, Heughbaert M, Biomaterials, 7, 97 (1986)
Thomas KA, Key JF, Kook SD, Jarcho M, J. Biomed. Mater. Res., 21, 1395 (1987)
Li P, Ohtsuki C, Kokubo T, Nakanishi K, Soga N, De Groot K, J. Biomed Mater. Res., 28, 7 (1994)
Li P, Kangasniemi, De Groot K, Kokubo T, J. Am. Ceram. Soc., 5, 1307 (1994)
LeGeros RZ, Calcium phosphates in oral biology and medicine, p. 12, Karger, Basel, Switzerland, (1991) (1991)
Eanes ED, Bonucci E, CRC Press, Boca Raton, USA, 1 (1992) (1992)
Jonasova L, Muller FA, Helebrant A, Strnad J, Greil P, Biomaterials, 25, 1187 (2004)
Kokubo T, Thermochim Acta, 280/281, 479 (1996)
Kokubo T, Miyaji F, Kim HM, J. Am. Ceram. Soc., 4, 1127 (1996)
Takatama H, Kim HM, Kokubo T, Nakamura T, J. Biomed Mater. Res., 57, 441 (2001)
Jonasova L, Muller F, Helebrant A, Strnad J, Greil P, Biomaterials, 23, 3095 (2002)
Eidelman N, Browm WE, Meyer JL, J. Crystal Growth, 113, 643 (1991)
Leng Y, Chen J, Qu S, Biomaterials, 24, 2125 (2003)
Lu X, Leng Y, Biomaterials, 25, 1779 (2004)
Murphy WL, Mooney DJ, J. Am. Chem. Soc., 124(9), 1910 (2002)
Pouilleau J, Devilliers E, Garrido F, Durand-Vidal S, Mahe E, Mater. Sci. Eng. B, 47, 235 (1997)
Kim J, Lee KH, Hong SI, Korean J. Mater. Res., 15(11), 690 (2005)
Rubin MA, Jasiuk I, Taylor J, Rubin J, Ganey T, Apkarian RP, Bone, 33, 270 (2003)
LANDIS WJ, SONG MJ, LEITH A, MCEWEN L, MCEWEN BF, J. Struct. Biol., 110(1), 39 (1993)
Su X, Sun K, Cui FZ, Landis EJ, Bone, 32, 150 (2003)
Aiziwa M, Porter AE, Best SM, Bonfield W, Biomaterials, 26, 3147 (2005)
Hong SI, Suryanarayana C, Mater. Trans. JIM, 42, 502 (2001)

[Referenced By]

[1] Kim HM, Miyaji F, Kokubo T, Nakamura T, J. Biomed. Mater. Res., 32, 409 (1996)

[2] Kokubo T, Miyaji F, Kim HM, Nakamura T, J. Am. Ceram. Soc., 79, 1127 (1996)

[3] Ohtsuki C, Idia H, Hayakawa S, Osaka A, J . Biomed. Mater. Res., 35, 39 (1997)

[4] Kaneko S, Tsuru K, Hayakawa S, Takemoto S, Ohtsuki C, Ozaki T, Inoue H, Biomaterials, 22, 875 (2001)

[5] Kokubo T, Kushitani H, Sakka S, Kitsugi T, Yammamuro T, J. Biomed. Mater. Res., 24, 721 (1990)

[6] De Groot K, Geesink RGf, Klein CPAT, Serekian P, J Biomed Mater Res., 21, 1375 (1987)

[7] Klein CAPT, Patka P, CAPT, Van der Lubbe HBM, Wolke JGC, De Grook K, J. Biomed. Mater. Res., 25, 53 (1991)

[8] Duchyene P, Van Earmodonck W, Heughbaert JC, Heughbaert M, Biomaterials, 7, 97 (1986)

[9] Thomas KA, Key JF, Kook SD, Jarcho M, J. Biomed. Mater. Res., 21, 1395 (1987)

[10] Li P, Ohtsuki C, Kokubo T, Nakanishi K, Soga N, De Groot K, J. Biomed Mater. Res., 28, 7 (1994)

[11] Li P, Kangasniemi, De Groot K, Kokubo T, J. Am. Ceram. Soc., 5, 1307 (1994)

[12] LeGeros RZ, Calcium phosphates in oral biology and medicine, p. 12, Karger, Basel, Switzerland, (1991) (1991)

[13] Eanes ED, Bonucci E, CRC Press, Boca Raton, USA, 1 (1992) (1992)

[14] Jonasova L, Muller FA, Helebrant A, Strnad J, Greil P, Biomaterials, 25, 1187 (2004)

[15] Kokubo T, Thermochim Acta, 280/281, 479 (1996)

[16] Kokubo T, Miyaji F, Kim HM, J. Am. Ceram. Soc., 4, 1127 (1996)

[17] Takatama H, Kim HM, Kokubo T, Nakamura T, J. Biomed Mater. Res., 57, 441 (2001)

[18] Jonasova L, Muller F, Helebrant A, Strnad J, Greil P, Biomaterials, 23, 3095 (2002)

[19] Eidelman N, Browm WE, Meyer JL, J. Crystal Growth, 113, 643 (1991)

[20] Leng Y, Chen J, Qu S, Biomaterials, 24, 2125 (2003)

[21] Lu X, Leng Y, Biomaterials, 25, 1779 (2004)

[22] Murphy WL, Mooney DJ, J. Am. Chem. Soc., 124(9), 1910 (2002)

[23] Pouilleau J, Devilliers E, Garrido F, Durand-Vidal S, Mahe E, Mater. Sci. Eng. B, 47, 235 (1997)

[24] Kim J, Lee KH, Hong SI, Korean J. Mater. Res., 15(11), 690 (2005)

[25] Rubin MA, Jasiuk I, Taylor J, Rubin J, Ganey T, Apkarian RP, Bone, 33, 270 (2003)

[26] LANDIS WJ, SONG MJ, LEITH A, MCEWEN L, MCEWEN BF, J. Struct. Biol., 110(1), 39 (1993)

[27] Su X, Sun K, Cui FZ, Landis EJ, Bone, 32, 150 (2003)

[28] Aiziwa M, Porter AE, Best SM, Bonfield W, Biomaterials, 26, 3147 (2005)

[29] Hong SI, Suryanarayana C, Mater. Trans. JIM, 42, 502 (2001)