PMMA를 이용한 다공질 β-TCP 골충진제 제조 및 생체적합성 평가

송호연; 윤민호; 김영희; 민영기; 양훈모; 이병택; Ho-Yeon Song; Min-Ho Youn; Young-Hee Kim; Young-Ki Min; Hun-Mo Yang; Byong-Taek Lee

Korean Journal of Materials Research, Vol.17, No.6, 318-322, June, 2007

DOI10.3740/MRSK.2007.17.6.318 Export Citation

PMMA를 이용한 다공질 β-TCP 골충진제 제조 및 생체적합성 평가

Fabrication of Porous β-TCP Bone Graft Substitutes Using PMMA Powder and their Biocompatibility Study

송호연, 윤민호¹, 김영희, 민영기², 양훈모², 이병택^{1, †}

순천향대학교 의과대학 미생물학교실
¹순천향대학교 의과대학 의공학교실
²순천향대학교 의과대학 생리학교실

Ho-Yeon Song, Min-Ho Youn¹, Young-Hee Kim², Young-Ki Min³, Hun-Mo Yang³, and Byong-Taek Lee^{1, †}

Department of Microbiology, School of Medincine, Soonchunhyang University, 366-1, Ssangyong-dong, Cheonan, Chungnam, 330-090, Korea
¹Department of Biomedical Engineering & Materials, School of Medicine, Soonchunhyang University, 366-1, Ssangyong-dong, Cheonan, Chungnam, 330-090, Korea
²Department of Microbiology, School of Medicine, Soonchunhyang University, 366-1, Ssangyong-dong, Cheonan, Chungnam, 330-090, Korea
³Department of Physiology, School of Medicine, Soonchunhyang University, 366-1, Ssangyong-dong, Cheonan, Chungnam, 330-090, Korea

E-mail:

Porous phosphate bioceramic was fabricated by pressureless sintering using commercial HAp and different volume percentages of PMMA powders (30-60 vol.%). The range of spherical pore size was about in diameter. By increasing the PMMA content, the number of pores and their morphology were dramatically changed as well as decreased the material properties. In case of using 60 vol.% PMMA content, network-type pores were found, due to the necking of the PMMA powders. The values of relative density, elastic modulus, bending strength and hardness of the 60 vol.% PMMA content sample, sintered at , were about 46%, 22.2 GPa, 5MPa and 182 Hv respectively. Human osteoblast-like MG-63 cells and osteoclast-like Raw 264.7 cells were well grown and fully covered all of the porous bodies sintered at .

Keywords:bone graft substitute;porous body;biocompatibility

[References]

Groot KD, Biomaterials, 1, 47 (1980)
Kang IC, Cho SH, Song HY, Lee BT, J. Kor. Ceram. Soc., 41, 560 (2004)
Moore DC, Chapman MW, Manske D, J. Orthop. Res., 5, 356 (1987)
Suchanek W, Yoshimera M, J. Mater. Res, 13, 94 (1998)
Daculsi G, Bouler JM, LeGeros RZ, Int. Rev. Cytol., 172, 129 (1997)
Tsui YC, Doyle C, Clyne TW, Biomaterials, 19, 2015 (1998)
Tsui YC, Doyle C, Clyne TW, Biomaterials, 19, 2031 (1998)
Kweh SWK, Khor KA, Cheang P, Biomaterials, 21, 1223 (2002)
Matsumoto T, Okazaki M, Inoue M, Hamada Y, Taira M, Takahashi J, Biomaterials, 23, 2241 (2002)
Manso M, Langlet M, Jimenez C, Martinez-Duart JM, Biomolecular Eng., 19, 63 (2002)
Yang YC, Chang E, Biomaterials, 22, 1827 (200)
Chenglin C, Jingchuan Z, Zhongda Y, Shidong W, Mater. Sci. Eng. A, 271, 95 (1999)
Ding SL, Su YM, Ju CP, Chern Lin JH, Biomaterials, 22, 833 (2001)
Youn MH, Paul RK, Song HY, Lee BT, Mater. Sci. Forum, 534, 49 (2007)
Asit GK, Song HY, Lee BT, Scrip. Mater., 54, 2081 (2006)
Fleurya C, Petita A, Mwalea F, Antonioua J, Zukora DJ, Tabrizianb M, Huka OL, Biomaterials, 27, 3351 (2006)
Xu HK, Carey LE, Simon G, Takagi S, Chow LC, Dent. Mater, In press (2006) (2006)
Callis PD, Donaldson K, McCord JF, Clinic. Mater., 3, 183 (1988)
Gauthier O, Bouler JM, Aguado E, Pilet P, Daculsi G, Biomaterials, 19, 133 (1998)
Lee CH, Youn MH, Song HY, Lee BT, J. Kor. Inst. Meter. Res., 15, 3 (2005)
Song HY, Kim YH, Ko KK, Kim YH, Oh IH, Lee BT, J. Kor. Inst. Met. Mater., 44, 6 (2006)

[1] Groot KD, Biomaterials, 1, 47 (1980)

[2] Kang IC, Cho SH, Song HY, Lee BT, J. Kor. Ceram. Soc., 41, 560 (2004)

[3] Moore DC, Chapman MW, Manske D, J. Orthop. Res., 5, 356 (1987)

[4] Suchanek W, Yoshimera M, J. Mater. Res, 13, 94 (1998)

[5] Daculsi G, Bouler JM, LeGeros RZ, Int. Rev. Cytol., 172, 129 (1997)

[6] Tsui YC, Doyle C, Clyne TW, Biomaterials, 19, 2015 (1998)

[7] Tsui YC, Doyle C, Clyne TW, Biomaterials, 19, 2031 (1998)

[8] Kweh SWK, Khor KA, Cheang P, Biomaterials, 21, 1223 (2002)

[9] Matsumoto T, Okazaki M, Inoue M, Hamada Y, Taira M, Takahashi J, Biomaterials, 23, 2241 (2002)

[10] Manso M, Langlet M, Jimenez C, Martinez-Duart JM, Biomolecular Eng., 19, 63 (2002)

[11] Yang YC, Chang E, Biomaterials, 22, 1827 (200)

[12] Chenglin C, Jingchuan Z, Zhongda Y, Shidong W, Mater. Sci. Eng. A, 271, 95 (1999)

[13] Ding SL, Su YM, Ju CP, Chern Lin JH, Biomaterials, 22, 833 (2001)

[14] Youn MH, Paul RK, Song HY, Lee BT, Mater. Sci. Forum, 534, 49 (2007)

[15] Asit GK, Song HY, Lee BT, Scrip. Mater., 54, 2081 (2006)

[16] Fleurya C, Petita A, Mwalea F, Antonioua J, Zukora DJ, Tabrizianb M, Huka OL, Biomaterials, 27, 3351 (2006)

[17] Xu HK, Carey LE, Simon G, Takagi S, Chow LC, Dent. Mater, In press (2006) (2006)

[18] Callis PD, Donaldson K, McCord JF, Clinic. Mater., 3, 183 (1988)

[19] Gauthier O, Bouler JM, Aguado E, Pilet P, Daculsi G, Biomaterials, 19, 133 (1998)

[20] Lee CH, Youn MH, Song HY, Lee BT, J. Kor. Inst. Meter. Res., 15, 3 (2005)

[21] Song HY, Kim YH, Ko KK, Kim YH, Oh IH, Lee BT, J. Kor. Inst. Met. Mater., 44, 6 (2006)