We present a multi-parametric model predictive controller (mpMPC) for discrete-time linear parameter-varying (LPV) systems based on the solution of the mpMPC problem for discrete-time linear time-invariant (LTI) systems, The control method yields a controller that adapts to parameter changes of the LPV system. This is accomplished by an add-on unit to the implementation of the mpMPC for LTI systems. No modification of the optimal mpMPC solution for LTI systems is needed. The mpMPC for LPV systems is entirely based on simple computational steps performed on-line. This control design method could improve the performance and robustness of a mpMPC for LPV systems with slowly varying parameters. We apply this method to process systems which suffer from slow variation of system parameters due, for example, to aging or degradation. As an illustrative example the reference tracking control problem of the hypnotic depth during intravenous anaesthesia is presented: the time varying system matrix mimics an external disturbance on the hypnotic depth. In this example the presented mpMPC for LPV systems shows a reduction of approximately 60% of the reference tracking error compared to the mpMPC for LTI systems. (C) 2014 Elsevier Ltd. All rights reserved.