An anionic indium porphyrin framework (UNLPF-10) consisting of rare Williams b-tetrakaidecahedral cages was constructed using an octatopic ligand linked with 4-connected [In(COO)(4)](-) SBUs. Remarkably, the extent of indium metalation of porphyrin macrocycles in UNLPF-10 can be facilely tuned in situ depending on the M/L ratio during synthesis, resulting in a controllable framework charge density and photocatalytic activity toward the selective oxygenation of sulfides.