The novel primary explosive tetranitrodiglycoluril (TNDGU) was synthesized from glycoluril dimer. It was fully characterized by using NMR (H-1, C-13), IR spectroscopy, and elemental analysis. X-ray diffraction revealed that the crystals of TNDGU belong to triclinic system with space group P (1) over bar. The thermal behavior of TNDGU was studied using DSC methods. TNDGU exhibited good thermal stability with a decomposition temperature of 284.8 degrees C. TNDGU was also more resistant to hydrolysis compared to other nitrourea analogues. Additionally, density, enthalpy of formation, detonation velocity (VOD), and detonation pressure of TNDGU were predicted and it was found that TNDGU is a potential powerful explosive with a calculated density of 1.93 g cm(-3), a detonation velocity of 8305 m s(-1) and low sensitivity to electric discharge.