The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates

Mihaela Violeta Ghica; Mădălina Georgiana Albu; Durmuș Alpaslan Kaya; Lăcrămioara Popa; Şevket Öztürk; Laura-Cristina Rusu; Cristina Dinu-Pîrvu; Ciprian Chelaru; Luminița Albu; Aurelia Meghea; Cornelia Nitipir

Korean Journal of Chemical Engineering, Vol.33, No.4, 1325-1330, April, 2016

DOI10.1007/s11814-015-0284-7 Export Citation

The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates

Mihaela Violeta Ghica, Mădălina Georgiana Albu^{1, †}, Durmuș Alpaslan Kaya², Lăcrămioara Popa, Şevket Öztürk³, Laura-Cristina Rusu^{4, †}, Cristina Dinu-Pîrvu, Ciprian Chelaru⁵, Luminița Albu¹, Aurelia Meghea⁵, and Cornelia Nitipir⁶

Physical and Colloidal Chemistry Department, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956, Bucharest, Romania
¹Collagen Department, INCDTP, Division Leather and Footwear Research Institute, 93 Ion Minulescu Str., 031215, Bucharest, Romania
²Department of Field Crops, Faculty of Agriculture, Mustafa Kemal University, 31030, Hatay, Turkey
³Institute of Natural and Applied Sciences, Mustafa Kemal University, 31034 Hatay, Turkey
⁴Victor Babeș University of Medicine and Pharmacy of Timisoara, 2 Piața Eftimie Murgu Str., 300041, Timișoara, Romania
⁵Politehnica University of Bucharest, 1 Polizu Str., 011061, Bucharest, Romania
⁶Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroilor Sanitari Blvd., 050513, Bucharest, Romania

E-mail:,

The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.

Keywords:Collagen Hydrolysate;Niflumic Acid;Lavandula Essential Oils;Release Kinetics

[References]

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[2] Ardalan A, Omid A, Golnaz A, Mahdi Z, J. Essent. Oil Bear Pl., 16(1), 59 (2013)

[3] Clardy J, Walsh C, Nature, 432(7019), 829 (2004)

[4] Gennadios A, McHugh TH, Weller CL, Krochta JM, Edible coatings and films based on proteins, Krochta JM, Baldwin EA, Nisperos-Carriedo M (Eds.), Edible coatings and films to improve food quality, Technomic Publishing Co., Lancaster (1994).

[5] Gomez-Guillen MC, Gimenez B, Lopez-Caballero ME, Montero MP, Food Hydrocolloids, 25(8), 1813 (2011)

[6] Rusu LC, Kaya DA, Ghica MV, Albu MG, Popa L, Butu A, Dinu-Pirvu CE, Dig. J. Nanomater. Bios., 9(1), 317 (2014)

[7] Ghica MV, Albu MG, Popa L, Moisescu S, Pharmazie, 68(5), 340 (2013)

[8] Popa L, Ghica MV, Albu MG, Ortan A, Dinu-Pirvu CE, Dig. J. Nanomater. Bios., 8(3), 937 (2013)

[9] Ficai A, Albu MG, Birsan M, Sonmez M, Ficai D, Trandafir V, Andronescu E, J. Mol. Struct., 1037, 154 (2013)

[10] Rao KP, J. Biomater. Sci.-Polym. Ed., 7(7), 623 (1995)

[11] Lee CH, Singla A, Lee Y, Int. J. Pharm., 221(1-2), 1 (2001)

[12] Shu-Tung L, Biologic Biomaterials: Tissue-Derived Biomaterials (Collagen), Park JB, Bronzino JD (Eds.), Biomaterials: Principles and Applications, CRC Press, Boca Raton, FL (2003).

[13] Barreto HM, Filho ECS, de O. Lima E, Coutinho DM, Morais-Braga MFB, Tvares CCA, Tintino SR, Rego JV, de Abreu APL, Lustosa MCG, Oliveira RWG, Cito AMGL, Lopes JAD, Ind. Crop. Prod., 59, 290 (2014)

[14] Bassole IHN, Juliani HR, Molecules, 17(4), 3989 (2012)

[15] Langhasova L, Hanusova V, Rezek J, Stohanslova B, Ambroz M, Kralova V, Vanek T, Lou JD, Yun ZL, Yang J, Skalova L, Ind. Crop. Prod., 59, 20 (2014)

[16] Adorjan B, Buchbauer G, Flavour Frag. J., 25(6), 407 (2010)

[17] Kim B, Kim HS, Korean J. Chem. Eng., 31(10), 1831 (2010)

[18] Yang ZF, Cao SF, Zheng YH, Food Chem., 125(2), 701 (2011)

[19] Raut JS, Karuppayil SM, Ind. Crop. Prod., 62, 250 (2014)

[20] Ocak B, J. Environ. Manage., 100, 22 (2012)

[21] Inan M, Kaya DA, Albu MG, Rev. Chim. (Bucharest), 64(9), 1037 (2013)

[22] Ahad A, Aqil M, Kohli K, Sultana Y, Mujeeb M, Expert Opin. Drug Deliv., 11(8), 1149 (2014)

[23] Nowak E, Combes G, Stitt EH, Pacek AW, Powder Technol., 233, 52 (2013)

[24] Depalo A, Santomaso AC, Colloids Surf. A: Physicochem. Eng. Asp., 436, 371 (2013)

[25] Ghica MV, Albu MG, Leca M, Popa L, Moisescu S, Pharmazie, 66(11), 853 (2011)

[26] Ghica MV, Albu MG, Coara G, Dinu-Pirvu C, Proceedings of the 4th International Conference on Advanced Materials and Systems (ICAMS), Bucharest, September 27-29, 267 (2012).

[27] Ahadian S, Mohseni M, Moradian S, Int. J. Adhes. Adhes., 29(4), 458 (2009)

[28] Peppas NA, Pharm. Acta. Helv., 60(4), 110 (1985)