Algicidal effects of thiazolinedione derivatives against Microcystis aeruginosa

Don-Sang You; Yeon Woong Lee; Dubok Choi; Young-Cheol Chang; Hoon Cho

Korean Journal of Chemical Engineering, Vol.34, No.1, 139-149, January, 2017

DOI10.1007/s11814-016-0234-z Export Citation

Algicidal effects of thiazolinedione derivatives against Microcystis aeruginosa

Don-Sang You, Yeon Woong Lee¹, Dubok Choi², Young-Cheol Chang³, and Hoon Cho^{1, †}

Leaders in Industry-University Cooperation Foundation, Chosun University, Gwangju 61452, Korea
¹Department of Polymer Science & Engineering, Chosun University, Gwangju 61452, Korea
²Biotechnology Laboratory, B-K Company Ltd., Jeonbuk 54008, Korea
³Biosystem Course, Division of Applied Sciences, Muroran Institute of Technology, 27-1 Mizumoto 050-8585, Japan

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Novel algicidal compounds against Microcystis aeruginosa were developed. A series of 64 thiazolidinedione (TD) derivatives were synthesized and analyzed for algicidal activity. Eleven compounds (2, 22, 38, 40, 49, 52, 54, 56, 58, 60, and 63) showed potent specific algicidal activity against M. aeruginosa with IC50 values <0.5 μM. An acute ecotoxicity test for these compounds was conducted using Danio rerio for ten days to verify their environmental impacts. Compounds 2 and 22 presented low ecotoxicity (EC50 13.59 and 8.59 μM, respectively). To evaluate the ecotoxic effect of various concentrations of compound 2, Daphnia magna were treated with 2.0, 2.3, 2.7, or 3.0 μM compound 2 for 25 days. Survival rate was 100% after 25 days in the 2.0 μM group, but declined to 96% at 8 days and 30% at 17 days in the 2.3 μM group. Our results indicate that compound 2 could be a potential bio-agent for controlling harmful algal blooms.

Keywords:Thiazolidinedione;Algicidal Activity;Microcystis aeruginosa;Ecotoxicity

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[2] Liu J, Zhang H, Yang W, Gao J, Ke Q, Mater. Res. Bull., 6, 60 (2004)

[3] Li FM, Hu HY, Appl. Environ. Microbiol., 71, 6545 (2005)

[4] Nagasaki K, Tomaru Y, Tarutani K, Katanozaka N, Yamanaka S, Tanabe H, Yamaguchi M, Appl. Environ. Microbiol., 69, 2580 (2003)

[5] Kim JS, Kim JC, Lee S, Lee BH, Cho KY, Aquatic Botany, 85, 1 (2006)

[6] Baek SH, Hong SS, Song SY, Lee HO, Nakano SI, Han MS, J. Freshw Ecol., 24, 367 (2009)

[7] Anderson DM, Ocean Coast Manage, 52, 342 (2009)

[8] Shirota A, Int. J. Aquat. Fish. Technol., 1, 195 (1989)

[9] Yu ZM, Zou JZ, Ma X, China J. Oceanol. Limnol., 12, 193 (1994)

[10] Na GH, Choi WJ, Chun YY, Korean J. Aquacult., 9, 239 (1996)

[11] Park TG, Lim WA, Park YT, Lee CK, Jeong HJ, Harm. Algae, 30S, S131 (2013)

[12] Shumway SE, Frank DM, Ewart LM, Ward JE, Aquacult Res., 34, 1391 (2003)

[13] Choi HG, Kim PJ, Lee WC, Yun SJ, Kim HG, Lee HJ, J. Korean Fish. Soc., 31, 109 (1998)

[14] Lee YJ, Choi JK, Kim EK, Youn SH, Yang EJ, Harmful Algae, 7, 154 (2008)

[15] Owens DR, Clin. Drug Invest., 22(8), 485 (2002)

[16] Kim YM, Wu Y, Duong TU, Ghodake GS, Kim SW, Jin E, Cho H, Appl. Biochem. Biotechnol., 162(8), 2273 (2010)

[17] Wu Y, Lee Y, Jung SG, Eom CY, Kim SW, Cho H, Jin ES, World J. Microbiol. Biotechnol., 30, 1603 (2014)

[18] Han HK, Kim YM, Lim SS, Hong SG, Cho H, Int. J. Pharm., 405, 137 (2011)

[19] Yim EC, Park IT, Han HK, Kim SI, Cho H, Kim SJ, Environ. Health Toxicol., 25, 273 (2010)

[20] Kim SJ, Yim EC, Park IT, Kim SW, Cho H, Environ. Toxicol. Chem., 30, 2810 (2011)

[21] Baek SH, Jang MC, Son MH, Joo HM, Cho HC, Kim YO, J. Korean Soc. Oceanog., 17, 9 (2012)

[22] Ye WJ, Tan J, Liu XL, Lin SQ, Pan JL, Li DT, Yang H, Harm. Algae, 10, 472 (2011)

[23] Zurawell RW, Chen H, Burke JM, Prepas EE, J. Toxicol. Environ. Health, 8, 1 (2005)

[24] Ross C, Santiago-Vazquez L, Paul V, Aquat. Toxicol., 78, 66 (2006)

[25] Li ZH, Geng MX, Yang H, Appl. Microbiol. Biotechnol., 99(2), 981 (2015)

[26] Kim YM, Wu Y, Duong TU, Jung SG, Kim SW, Cho H, Jin ES, Mar. Biotechnol., 14, 312 (2012)