Gold and silver nanoparticles green synthesized using an aqueous extract of geranium (Pelargonium graveolens) leaves were embedded in cholesterol-containing dipalmitoyl phosphatidylcholine lipid vesicles by a simple eco-friendly method, resulting in bio-based composites with antioxidant and antibacterial properties. The artificial lipid bilayers were loaded with chlorophyll a, in order to get a deeper insight into the biocomposite formation monitored by fluorescence emission spectroscopy. These silver and gold-based biohybrids exhibited good stability and antioxidant activity. Antimicrobial investigations against Escherichia coli ATCC 8738 revealed that these bio-based composites were the most potent biocides.