The novel 3D plotted plug-flow reactor, which is built up like an inverse packed-bed reactor, represents an interesting option to other innovative chemical reactors relating to process intensification. For this work, the reactor was integrated in a suitable layout. This pilot plant unit should permit miscellaneous chemical reactions under inherently secure conditions. Heterogeneously catalyzed multiphase reactions with medium to high heat content are in the main focus. An oxidative cyclization was chosen as a suitable model reaction for this pilot plant unit.