천연 항균물질을 함유한 창상치료용 폴리우레탄 폼 드레싱재의 제조 및 특성연구

김원일; 고영광; 박미란; 정경혜; 권오형; Won Il Kim; Young-Gwang Ko; Mi Ran Park; Kyung Hye Jung; Oh Hyeong Kwon

Polymer(Korea), Vol.42, No.5, 806-812, September, 2018

DOI10.7317/pk.2018.42.5.806 Export Citation

천연 항균물질을 함유한 창상치료용 폴리우레탄 폼 드레싱재의 제조 및 특성연구

Preparation and Characterization of Polyurethane Foam Dressings Containing Natural Antimicrobial Agents for Wound Healing

김원일^{1, 2}, 고영광², 박미란², 정경혜³, 권오형 ^{2, †}

¹(주)원바이오젠 기술연구소
²금오공과대학교 고분자공학과
³대구가톨릭대학교 신소재화학공학과

Won Il Kim^{1, 2}, Young-Gwang Ko², Mi Ran Park², Kyung Hye Jung³, and Oh Hyeong Kwon^{2, †}

¹R&D Center, Wonbiogen Co., Ltd., Gumi, Gyeongbuk 39372, Korea
²Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyeongbuk 39177, Korea
³Department of Advanced Materials and Chemical Engineering, Catholic University of Daegu, Gyeongsan, Gyeongbuk 38430, Korea

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초록

폼 드레싱재는 창상부위의 삼출물을 지속적으로 흡수하며 습윤환경을 유지하므로, 세균증식의 취약점이 있다. 그러므로 습윤환경 폼 드레싱재의 개발에서 항균성 부여는 중요한 요소 중 하나이다. 본 연구에서는 천연 항균물질인 병풀의 유효성분(asiatic acid, madecassic acid, aciaticoside)을 활용하여 항균성 폼 드레싱재를 제조 후 창상치료 효과를 검증하고자 하였다. 기존의 창상피복용 폴리우레탄 폼 드레싱재의 물성보다 개선된 흡수층을 제조하기 위해 발포혼합액과 항균성분의 배합비에 따른 기계적 물성, 기공형태, 흡수도 및 흡수속도를 분석 후 최적조건을 확립하였다. 병풀의 유효성분을 함유한 폼은 높은 항균능을 나타내었으며 동물모델 실험에서 우수한 창상회복률을 보여주었다. 병풀의 유효성분이 함유된 폴리우레탄 폼 드레싱재는 항균성 창상치료용 소재로서의 응용 가능성이 기대된다.

The foam dressing material continuously absorbs the exudate of the wound area and maintains moisture environment, so that there is a weak point of the bacterial growth. Therefore, antimicrobial property is one of the important factors in the development of moisture environment foam dressing. The purpose of this study is to evaluate the effectiveness of wound dressing after manufacturing antimicrobial foam dressing materials containing asiatic acid, madecassic acid, and aciaticoside of the Centella asiatica. In order to fabricate superior absorbent layer compared to conventional polyurethane foam dressings, the optimum mechanical properties, pore morphology, absorbency and absorption rate were established on blending ratio of the foam mixture and the antimicrobial component. The foam containing the active ingredients of the Centella asiatica showed high antimicrobial activity and excellent wound recovery rate in animal model experiments. The polyurethane foam dressing material containing active ingredients of the Centella asiatica is expected to be used as an antimicrobial wound treatment.

Keywords:polyurethane;asiatic acid;madecassic acid;asiaticoside;antimicrobial

[References]

Korean Research Group for Wound Care, Advance in Wound Care, Korean Medical Book Publisher, Seoul, 2002.
Winter GD, Nature, 193, 293 (1962)
Kifune K, Medical Application of chitin and chitosan, Yangseogak, Seoul, 2001.
Dumitrui S, Polymeric Biomaterials, Marcel Dekker, New York, 1994.
Lelah MD, Copper SL, Polyurethane in Medicines, CRC Press, Boca Raton, Florida, 1986.
Park KD, Kim YS, Han DK, Kim YH, Lee EHB, Suh H, Choi KS, Biomaterials, 19, 851 (1998)
Dounis DV, Wilkes GL, Polymer, 38(11), 2819 (1997)
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Nielsen J, Fogh K, Chronic Wound Care Manag. Res., 2, 31 (2015)
Pyun DG, Yoon HS, Chung HY, Choi HJ, Thambi T, Kim BS, Lee DS, J. Mater. Chem. B, 3, 7752 (2015)
Smirnov SV, Shakhlamov MV, Litnsky MA, Yanshin DV, Sachkov AV, Obolensky VN, Wound Medicine, 2, 6 (2013)
Oh ST, Kim SH, Jeong HY, Lee JM, Cho JW, Park JS, Fiber Polym., 14, 173 (2013)
Hausen BM, Contact Dermatitis, 29, 175 (1993)
Brinkhaus B, Linder M, Schuppan D, Hahn EG, Phytomedicine, 7, 427 (2000)
Bonte F, Dumas M, Chaudagne C, Meybeck A, Planta Med., 60, 133 (1993)
Maquart FX, Bellon G, Gillery P, Wegrowski Y, Borel JP, Connect. Tissue Res., 24, 107 (1990)
Kim OT, Kim MY, Kim SJ, Kim YJ, Kim KS, Ahn JC, Kim SW, Hwang B, Korean J. Med. Crop Sci., 10, 375 (2002)
Binh NT, Oanh HN, Int. J. Pharm. Sci. Invent., 6, 15 (2017)
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Oertel G, Polyurethane handbook, 2nd ed, Hanser Publishers, New York, 1993.
Kim HJ, Polyurethane resin, Daekoang Publishers, Seoul, 1979.
Ashida K, Polyurethane and Related Foams: Chemistry and Technology, Taylor & Francis, Boca Roton, 2006.
Song KC, Lee SM, Lee DH, Polym. Korea, 25(5), 679 (2001)
Koh SH, Kim SB, Appl. Chem., 7(1), 29 (2003)
Baek WS, Lee KY, Polym. Korea, 25(4), 528 (2001)
Havens PL, Rase HF, Ind. Eng. Chem. Res., 32, 2254 (1993)
Kim YJ, Lee SW, Hong SH, Lee HK, Kim EK, J. Korean Soc. Aesthetic Plast. Surg., 5, 1170 (1999)
Kim WI, Kim CJ, Kim DY, Kwon OK, Kwon OH, Polym. Korea, 34(5), 442 (2010)

[Related Articles]

[1] Korean Research Group for Wound Care, Advance in Wound Care, Korean Medical Book Publisher, Seoul, 2002.

[2] Winter GD, Nature, 193, 293 (1962)

[3] Kifune K, Medical Application of chitin and chitosan, Yangseogak, Seoul, 2001.

[4] Dumitrui S, Polymeric Biomaterials, Marcel Dekker, New York, 1994.

[5] Lelah MD, Copper SL, Polyurethane in Medicines, CRC Press, Boca Raton, Florida, 1986.

[6] Park KD, Kim YS, Han DK, Kim YH, Lee EHB, Suh H, Choi KS, Biomaterials, 19, 851 (1998)

[7] Dounis DV, Wilkes GL, Polymer, 38(11), 2819 (1997)

[8] Stashak TS, Farstvedt E, Othic A, Clin. Tech. Equine. Pract., 3, 148 (2004)

[9] Nielsen J, Fogh K, Chronic Wound Care Manag. Res., 2, 31 (2015)

[10] Pyun DG, Yoon HS, Chung HY, Choi HJ, Thambi T, Kim BS, Lee DS, J. Mater. Chem. B, 3, 7752 (2015)

[11] Smirnov SV, Shakhlamov MV, Litnsky MA, Yanshin DV, Sachkov AV, Obolensky VN, Wound Medicine, 2, 6 (2013)

[12] Oh ST, Kim SH, Jeong HY, Lee JM, Cho JW, Park JS, Fiber Polym., 14, 173 (2013)

[13] Hausen BM, Contact Dermatitis, 29, 175 (1993)

[14] Brinkhaus B, Linder M, Schuppan D, Hahn EG, Phytomedicine, 7, 427 (2000)

[15] Bonte F, Dumas M, Chaudagne C, Meybeck A, Planta Med., 60, 133 (1993)

[16] Maquart FX, Bellon G, Gillery P, Wegrowski Y, Borel JP, Connect. Tissue Res., 24, 107 (1990)

[17] Kim OT, Kim MY, Kim SJ, Kim YJ, Kim KS, Ahn JC, Kim SW, Hwang B, Korean J. Med. Crop Sci., 10, 375 (2002)

[18] Binh NT, Oanh HN, Int. J. Pharm. Sci. Invent., 6, 15 (2017)

[19] Ahn B, Extraction method of aciaticoside, asiatic acid and madecassic acid from Centella asiatica, Korean Intellectual Property Office, No. 1985-000641 (1987).

[20] Oertel G, Polyurethane handbook, 2nd ed, Hanser Publishers, New York, 1993.

[21] Kim HJ, Polyurethane resin, Daekoang Publishers, Seoul, 1979.

[22] Ashida K, Polyurethane and Related Foams: Chemistry and Technology, Taylor & Francis, Boca Roton, 2006.

[23] Song KC, Lee SM, Lee DH, Polym. Korea, 25(5), 679 (2001)

[24] Koh SH, Kim SB, Appl. Chem., 7(1), 29 (2003)

[25] Baek WS, Lee KY, Polym. Korea, 25(4), 528 (2001)

[26] Havens PL, Rase HF, Ind. Eng. Chem. Res., 32, 2254 (1993)

[27] Kim YJ, Lee SW, Hong SH, Lee HK, Kim EK, J. Korean Soc. Aesthetic Plast. Surg., 5, 1170 (1999)

[28] Kim WI, Kim CJ, Kim DY, Kwon OK, Kwon OH, Polym. Korea, 34(5), 442 (2010)