화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korea-Australia Rheology Journal, Vol.32, No.1, 15-27, February, 2020
DOI10.1007/s13367-020-0003-8  Export Citation
Microfluidic-based effective monitoring of bloods by measuring RBC aggregation and blood viscosity under stepwise varying shear rates
Yang Jun Kang†
  • Department of Mechanical Engineering, Chosun University, Gwangju 61452, Republic of Korea
E-mail:
To effectively discriminate changes in blood samples, RBCs aggregation and blood viscosity should be evaluated independently and simultaneously. In this study, by setting two syringe pumps for delivering two fluids (blood sample and reference fluid) at stepwise varying flow rates, RBCs aggregation (AI ) and viscosity (μ Blood) are sequentially measured by quantifying image intensity of blood flows () and interface between blood sample and reference fluid (μ Blood) in microfluidic channels. The () for measuring AI was obtained at lower shear rate (γ< 91.7 s-1). Additionally, μBlood for measuring μ Blood was obtained at higher shear rates (γ> 91.7 s-1). As a demonstration, the proposed method is employed to measure AI and μBlood for various blood samples composed of different concentrations of dextran solution or different degrees in RBCs deformability. After then, the method is employed to measure AI and μBlood of blood samples with respect to storage time of 25 days. As a result, RBCs aggregation and blood viscosity varied continuously up to 15 days of storage time. In conclusion, this method can be used effectively to detect changes in blood samples by measuring μBlood and AI of blood samples simultaneously.
Keywords:blood viscosity;RBC aggregation;power-law formula;microfluidic device;blood storage time;co-flowing streams;image intensity variations;increasing flow rate mode (IFM)
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