The solubility of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) in 12 pure solvents was measured in the temperature range of 298.15-358.15 K by the static equilibrium method through high-performance liquid chromatography (HPLC) at the atmospheric pressure, including dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP), N,N-dimethylformamide (DMAC), 1,4-butyrolactone (BL), triethyl phosphate, propylene carbonate, N,N-dimethylformamide (DMF), cyclohexanone, cyclopentanone, acetonitrile, acetone, and pyridine. The experimental solubility data were correlated with three thermodynamic models, including the modified Apelblat model, the Yaws model, and the ideal solution model. Experimental data indicate that the solubility of HMX increases with increasing temperature in all test solvents, and three kinds of thermodynamic models gave satisfactory correlations. All of these results lay the foundation for the crystallization process study of HMX and provide guidance for the use of suitable crystallization methods in different solvents.