화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.89, 58-82, September, 2020
DOI10.1016/j.jiec.2020.06.017  Export Citation
A comprehensive review on polymeric hydrogel and its composite: Matrices of choice for bone and cartilage tissue engineering
Huong D.N. Tran1, 2, Ki Dong Park3, Yern Chee Ching4, Cong Huynh5, †, and Dai Hai Nguyen6, 7, †
  • 1Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane 4072, Australia
  • 2Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Viet Nam, Australia
  • 3Department of Molecular Science and Technology, Ajou University, Suwon 16499, Republic of Korea
  • 4Department of Chemical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 5Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam, Vietnam
  • 6Institute of Applied Materials Science, Vietnam Academy of Science and Technology, 01 TL29, District 12, Ho Chi Minh City 700000, Viet Nam, Vietnam
  • 7Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Viet Nam, Vietnam
E-mail:,
The need of tissue and organ for transplantation to repair or replace damaged tissues is significantly higher than the availability of donated organs. Tissue engineering that develops functional substitutes for damaged tissues and organs via employing a combination of 3D biomaterials, supportive bioactive molecules, and/or living cells followed by in vitro culture and/or in vivo implantation, therefore, has attracted much attention in engineering the substitutes. Among 3D biomaterials, hydrogel materials have been extensively explored as matrices for skeletal regeneration because of their biocompatibility, tailorable mechanical properties, flexibility in fabrication, and ability to encapsulate cells and bioactive factors for their sustained, localized and controlled presentation. This review focuses on polymeric hydrogels and theirs composites for both bone and cartilage regeneration, including required properties, design and fabrication, functioned as bared biomaterials or delivery vehicles of bioactive molecules and/ or cells together with remaining challenges and future perspectives, emphasizing on the last few years.
Keywords:Hydrogel;Bone;Cartilage;Tissue engineering;Delivery system;Growth factors and cells
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