Fully biodegradable polymer stents still suffer from weak mechanical properties and thick stent struts, which could induce thrombosis under in vivo clinical applications. To address these problems, we fabricated a thinner poly(L-lactic acid) (PLLA) tube with improved mechanical properties through a thermal drawing process and characterized the tubes using several analytical tools. The mechanical properties of the tubes showed that the optimized conditions for the axial drawing were at 65 °C (A65) and 95 °C (A95), and those for the radial drawing process were also at 65 °C (R65) and 95 °C (R95). The bidirectional drawing process (A65/R95), performed at 65 °C for axial and then at 95 °C for radial drawings, demonstrated an excellent way to reduce the thickness of the tubes while reinforcing the mechanical properties. In addition, it reduced the amount of adsorbed fibrinogen and increased the albumin/ fibrinogen ratio. Moreover, the platelet adhesion exhibited lower number and activity with completely round morphology. It also promoted the adhesion and proliferation of endothelial cells with stretched morphology and a significant increase of filopodial outgrowth. From these results, it can be seen that a combination of the axial and radial processes may be a promising strategy for improving the physicochemical, mechanical, and biological properties of PLLA tubes to be used for the fabrication of fully biodegradable polymeric stents.