Optimization of the Preparation and Characterization of Tannylated-Albumin Nanoagents

Yeong Jun Song; Sung Yun Jung; Jin Hyuk Kim; Kyeongsoon Park

Macromolecular Research, Vol.28, No.11, 969-972, October, 2020

DOI10.1007/s13233-020-8141-x Export Citation

Optimization of the Preparation and Characterization of Tannylated-Albumin Nanoagents

Yeong Jun Song, Sung Yun Jung, Jin Hyuk Kim, and Kyeongsoon Park^†

Department of Systems Biotechnology, Chung-Ang University, Anseong, Gyeonggi 17546, Korea

E-mail:

We optimized the preparation of tannylated-human serum albumin (TA-HSA) nanoagents including indocyanine green (ICG) and lobeglitazone (Lobe)-loaded complexes by simple mixing and characterized them. We set the optimal pH at 5 and the optimal weight ratio of [TA]/[HSA] at 1.5 when considering the redispersion of the prepared suspensions in PBS (pH 7.4) and incubation at 37 ·C for the preparation of ICG and/or Lobe-loaded TA-HSA complexes. The immobilization of methoxy polyethylene glycol (mPEG) molecules on TA-HSA-ICG complexes significantly reduces the mean and Z-average sizes of these complexes from the microscale to the nanoscale. Moreover, the use of ICG increases the drug loading efficiency when preparing mPEG-TA-HSA-ICG/Lobe.

Keywords:tannic acid;albumin;protein-based carrier;nanoagent

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[1] Couvreur P, Adv. Drug Deliv. Rev., 65, 21 (2013)

[2] Huang J, Lin L, Sun D, Chen H, Yang D, Li Q, Chem. Soc. Rev., 44, 6330 (2015)

[3] Santos HA, Makila E, Airaksinen AJ, Bimbo LM, Hirvonen J, Nanomedicine, 9, 535 (2014)

[4] Ali I, Alsehli M, Scotti L, Scotti MT, Tsai ST, Yu RS, Hsieh MF, Chen JC, Polymers, 12, 598 (2020)

[5] Parodi A, Miao J, Soond SM, Rudzinska M, Zamyatnin AA, Biomolecules, 9, 218 (2019)

[6] Ryan SM, Brayden DJ, Curr. Opin. Pharmacol., 18, 120 (2014)

[7] Encinas-Basurto D, Ibarra, Juarez J, Pardo A, Taboada SBT, Valdez MA, Mater. Sci. Eng. C-Biomimetic Supramol. Syst., 91, 669 (2018)

[8] Ghorbani M, Hamishehkar H, Tabibiazar M, Macromol. Res., 26(9), 808 (2018)

[9] Jose LM, Kuriakose S, Macromol. Res., 27(7), 670 (2019)

[10] Kratz F, J. Control. Release, 132, 171 (2008)

[11] Kim B, Seo B, Park S, Lee C, Kim JO, Oh KT, Lee ES, Choi HG, Youn YS, Colloids Surf. B: Biointerfaces, 158, 157 (2017)

[12] Zhao Y, Cai C, Liu M, Zhao Y, Pei W, Chu X, Zhang H, Wang Z, Han J, Colloids Surf. B: Biointerfaces, 183, 110394 (2019)

[13] Asghar S, Salmani JMM, Hassan W, Xie Y, Meng F, Su Z, Sun M, Xiao Y, Ping Q, Eur. J. Pharm. Sci., 63, 53 (2014)

[14] Dai J, Mumper RJ, Molecules, 15, 7313 (2010)

[15] Sileika TS, Barrett DG, Zhang R, Lau KHA, Messersmith PB, Angew. Chem.-Int. Edit., 52, 10766 (2013)

[16] Belton DH, Deschaume O, Patwardhan SV, Perry CC, Chem. Commun., 114, 9947 (2010)

[17] Liang H, Pei Y, Li J, Xiong W, He Y, Liu S, Li Y, Li B, RSC Adv., 6, 31374 (2016)

[18] Shin M, Ryu JH, Park JP, Kim K, Yang JW, Lee H, Adv. Funct. Mater., 25(8), 1270 (2015)

[19] Shukla A, Fang JC, Puranam S, Jensen FR, Hammond PT, Adv. Mater., 24(4), 492 (2012)

[20] Heijmen FH, du Pont JS, Middelkoop E, Kreis RW, Hoekstra MJ, Biomaterials, 18, 749 (1997)

[21] Shin M, Lee HA, Lee M, Shin Y, Song JJ, Kang SW, Nam DH, Jeon EJ, et la., Nat. Biomed. Eng., 2, 304 (2018)

[22] Siebert KJ, Troukhanova NV, Lynn PY, J. Agric. Food Chem., 44, 80 (1996)

[23] Choi JY, Ryu J, Kim HJ, Song JW, Jeon JH, Lee DH, Oh DJ, Gweon DG, et al., Theranostics, 8, 45 (2018)

[24] Park S, Ahn JW, Jo Y, Kang HY, Kim HJ, Cheon Y, Kim JW, Park Y, Lee S, Park K, ACS Nano, 14, 1856 (2020)

[25] Perez-Maldonado RA, Norton BW, Kerven GL, J. Sci. Food Agric., 69, 291 (1995)

[26] Hagerman AE, Butler LG, J. Agric. Food Chem., 26, 809 (1978)

[27] Kosaka N, Mitsunaga M, Longmire MR, Choyke PL, Kobayashi H, Int. J. Cancer, 129, 1671 (2011)

[28] Vinegoni C, Botnaru I, Aikawa E, Calfon MA, Iwamoto Y, Folco EJ, Ntziachristos V, Weissleder R, Libby P, Jaffer FA, Sci. Transl. Med., 3, 84ra45 (2011)

[29] Shin M, Kim K, Shim W, Yang JW, Lee H, ACS Biomater. Sci. Eng., 2, 687 (2016)

[30] Thomas JC, J. Colloid Interface Sci., 117, 187 (1987)

[31] Aguilera JA, Venegas V, Oliva JM, Sayagues MJ, de Miguel M, Sanchez-Alcazar JA, Arevalo-Rodriguez M, Zaderenko AP, RSC Adv., 6, 7279 (2016)

[32] Saxena V, Sadoqi M, Shao J, J. Pharm. Sci., 92, 2090 (2003)

[33] Wang YG, Kim H, Mun S, Kim D, Choi Y, Quant. Imaging Med. Surg., 3, 132 (2013)