Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery

Young Chul Cho; Wooram Park; Jeon Min Kang; Dae Sung Ryu; Yubeen Park; Jae-Won Seo; Young Gook Koh; Jung-Hoon Park; Ji Hoon Shin

Macromolecular Research, Vol.29, No.2, 178-184, February, 2021

DOI10.1007/s13233-021-9022-7 Export Citation

Newly Developed N-butyl Cyanoacrylate (EG glue) for Arterial Embolization: A Preclinical Study in Rabbit Renal Artery

Young Chul Cho, Wooram Park¹, Jeon Min Kang², Dae Sung Ryu², Yubeen Park², Jae-Won Seo³, Young Gook Koh³, Jung-Hoon Park^{2, †}, and Ji Hoon Shin^†

Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
¹Department of Biomedical-Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Bucheon-si, Gyeonggi 14662, Korea
²Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
³R&D Center, ENGAIN Co., Ltd. Korea Bio Park BLD C 2F, 700 Daewangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi 13488, Korea

E-mail:,

N-Butyl cyanoacrylate (NBCA) glue has been widely utilized for the endovascular management of various vascular pathologies ranging from acute visceral hemorrhage to arteriovenous malformations. Here, we investigate the effectiveness and safety of the newly developed NBCA glue (i.e., EG glue) compared to conventional glue (Histoacryl) for transcatheter arterial embolization (TAE) in rabbit renal arteries. Compared to Histoacryl, EG glue had similar physical properties and embolic efficacy. In both groups, necrotizing lesions in the vessel walls were observed in all rabbits, without significant differences. Based on these results, we believe that EG glue could be a promising alternate embolic material for treating various diseases.

Keywords:embolization;N-butyl cyanoacrylate;embolic materials;arterial diseases;renal disease

[References]

Huang CC, Lee CW, Hsiao JK, Leung PC, Liu KL, Tsang YM, Liu HM, J. Vasc. Interv. Radiol., 22, 1594 (2011)
Kim PH, Tsauo J, Shin JH, Yun SC, J. Vasc. Interv. Radiol., 28, 522 (2017)
Picel AC, Koo SJ, Roberts AC, Cardiovasc. Int. Radiol., 39, 1170 (2016)
Uller W, El-Sobky S, Alomari AI, Fishman SJ, Spencer SA, Taghinia AH, Chaudry G, Vasc. Endovasc. Surg., 52, 269 (2018)
Hill H, Chick JFB, Hage A, Srinivasa RN, Diagn. Interv. Radiol., 24, 98 (2018)
Song HH, Won YD, Kim YJ, J. Vasc. Interv. Radiol., 21, 1508 (2010)
Yamakado K, Nakatsuka A, Tanaka N, Takano K, Matsumura K, Takeda K, J. Vasc. Interv. Radiol., 11, 66 (2000)
Denys A, Lacombe C, Schneider F, Madoff DC, Doenz F, Qanadli SD, Halkic N, Sauvanet A, Vilgrain V, Schnyder P, J. Vasc. Interv. Radiol., 16, 1667 (2005)
Kish JW, Katz MD, Marx MV, Harrell DS, Hanks SE, J. Vasc. Interv. Radiol., 15, 689 (2004)
Lee CW, Liu KL, Wang HP, Chen SJ, Tsang YM, Liu HM, J. Vasc. Interv. Radiol., 18, 209 (2007)
Stavropoulos SW, Kim H, Clark TWI, Fairman RM, Velazquez O, Carpenter JP, J. Vasc. Interv. Radiol., 16, 857 (2005)
Cimsit NC, Baltacioglu F, Cengic I, Akpinar IN, Ilker Y, Turkeri L, Int. Urol. Nephrol., 40, 875 (2008)
The n-BCA Trial Investigators, Am. J. Neuroradiol., 23, 748 (2002).
Park JH, Kim HC, Chung JW, Jae HJ, Park JH, Korean J. Radiol., 10, 361 (2009)
Yonemitsu T, Kawai N, Sato M, Sonomura T, Takasaka I, Nakai M, Minamiguchi H, Sahara S, Iwasaki Y, Naka T, Shinozaki M, Cardiovasc. Inter. Radiol., 33, 1192 (2010)
Li Y, Barthes-Biesel D, Salsac AV, J. Mech. Behav. Biomed. Mater., 69, 307 (2017)
Stoesslein F, Ditscherlein G, Romaniuk P, Cardiovasc. Inter. Radiol., 5, 264 (1982)
Takasawa C, Seiji K, Matsunaga K, Matsuhashi T, Ohta M, Shida S, Takase K, Takahashi S, J. Vasc. Interv. Radiol., 23, 1215 (2012)
Bank W, Kerber C, Cromwell L, Radiology, 139, 609 (1981)
Pollak JS, White RI, J. Vasc. Interv. Radiol., 12, 907 (2001)

[1] Huang CC, Lee CW, Hsiao JK, Leung PC, Liu KL, Tsang YM, Liu HM, J. Vasc. Interv. Radiol., 22, 1594 (2011)

[2] Kim PH, Tsauo J, Shin JH, Yun SC, J. Vasc. Interv. Radiol., 28, 522 (2017)

[3] Picel AC, Koo SJ, Roberts AC, Cardiovasc. Int. Radiol., 39, 1170 (2016)

[4] Uller W, El-Sobky S, Alomari AI, Fishman SJ, Spencer SA, Taghinia AH, Chaudry G, Vasc. Endovasc. Surg., 52, 269 (2018)

[5] Hill H, Chick JFB, Hage A, Srinivasa RN, Diagn. Interv. Radiol., 24, 98 (2018)

[6] Song HH, Won YD, Kim YJ, J. Vasc. Interv. Radiol., 21, 1508 (2010)

[7] Yamakado K, Nakatsuka A, Tanaka N, Takano K, Matsumura K, Takeda K, J. Vasc. Interv. Radiol., 11, 66 (2000)

[8] Denys A, Lacombe C, Schneider F, Madoff DC, Doenz F, Qanadli SD, Halkic N, Sauvanet A, Vilgrain V, Schnyder P, J. Vasc. Interv. Radiol., 16, 1667 (2005)

[9] Kish JW, Katz MD, Marx MV, Harrell DS, Hanks SE, J. Vasc. Interv. Radiol., 15, 689 (2004)

[10] Lee CW, Liu KL, Wang HP, Chen SJ, Tsang YM, Liu HM, J. Vasc. Interv. Radiol., 18, 209 (2007)

[11] Stavropoulos SW, Kim H, Clark TWI, Fairman RM, Velazquez O, Carpenter JP, J. Vasc. Interv. Radiol., 16, 857 (2005)

[12] Cimsit NC, Baltacioglu F, Cengic I, Akpinar IN, Ilker Y, Turkeri L, Int. Urol. Nephrol., 40, 875 (2008)

[13] The n-BCA Trial Investigators, Am. J. Neuroradiol., 23, 748 (2002).

[14] Park JH, Kim HC, Chung JW, Jae HJ, Park JH, Korean J. Radiol., 10, 361 (2009)

[15] Yonemitsu T, Kawai N, Sato M, Sonomura T, Takasaka I, Nakai M, Minamiguchi H, Sahara S, Iwasaki Y, Naka T, Shinozaki M, Cardiovasc. Inter. Radiol., 33, 1192 (2010)

[16] Li Y, Barthes-Biesel D, Salsac AV, J. Mech. Behav. Biomed. Mater., 69, 307 (2017)

[17] Stoesslein F, Ditscherlein G, Romaniuk P, Cardiovasc. Inter. Radiol., 5, 264 (1982)

[18] Takasawa C, Seiji K, Matsunaga K, Matsuhashi T, Ohta M, Shida S, Takase K, Takahashi S, J. Vasc. Interv. Radiol., 23, 1215 (2012)

[19] Bank W, Kerber C, Cromwell L, Radiology, 139, 609 (1981)

[20] Pollak JS, White RI, J. Vasc. Interv. Radiol., 12, 907 (2001)