Synthesis of ammonia through photo- and electrocatalysis is a rapidly growing field. Titania-based catalysts are widely reported for photocatalytic ammonia synthesis and have also been suggested as electrocatalysts. The addition of transition-metal dopants is one strategy for improving the performance of titania- based catalysts. In this work, we screend-block transition- metal dopants for surface site stability and evaluate trends in their performance as the active site for the reduction of nitrogen to ammonia on TiO2. We find a linear relationship between thed-band center and metal substitution energy of the dopant site, while the binding energies of N-2, N2H, and NH(2)all are strongly correlated with the cohesive energies of the dopant metals. The activity of the metal-doped systems shows a volcano type relationship with the NH(2)and N2H energies as descriptors. Some metals such as Co, Mo, and V are predicted to slightly improve photo- and electrocatalytic performance, but most metals inhibit the ammonia synthesis reaction. The results provide insight into the role of transition-metal dopants for promoting ammonia synthesis, and the trends are based on unexpected electronic structure factors that may have broader implications for single-atom catalysis and doped oxides.