Hypothesis: The spontaneous displacement of both spreading and receding droplets on surfaces are extensively involved in numerous technical applications. We hypothesize that the spreading and receding displacement behaviors could be interpreted differently due to opposite flow directions at the threephase contact line. Experiments: We performed two groups of displacement experiments using different initial setups of oil droplets on silanized glass surfaces in aqueous surroundings. Findings: The different initial configurations mostly resulted in oil displacement in opposite directions: either spreading or receding of the oil droplet. Different static states were observed at the end of the spreading and receding processes on surfaces with the same wettability due to the contact angle hysteresis. The dynamic displacement was analyzed using the hydrodynamic and molecular kinetic models, which showed distinct applicabilities for the data description of the spreading and receding possesses. The model analysis further indicated the different nature of these possesses, in particular, the resistance to displacement dynamics, which was illustrated by the interpretation of the microscopic slip length and contact line friction in the respective models. This study can shed light on the fundamental role of the displacement direction in the spontaneous liquid-liquid displacement. (c) 2020 Elsevier Inc. All rights reserved.