PolyHEMA Beads 제조에 관한 형태학적 연구

임재홍; 장우진; 김한성; 전경용; 한학수; 조영일

HWAHAK KONGHAK, Vol.36, No.6, 887-895, December, 1998

Export Citation

PolyHEMA Beads 제조에 관한 형태학적 연구

A Morphological Study on the Preparation of PolyHEMA Beads

임재홍, 장우진, 김한성, 전경용, 한학수, 조영일

초록

Poly(hydroxyethylmethacrylate)(polyHEMA) beads를 현탁중합법으로 제조하였으며, 중합에 사용된 1-octanol과 PVP (poly(N-vinyl-2-pyrrolidone) K-90)가 polyHEMA beads의 형태, 크기분포, 기공도 그리고 기공 평균반지름에 미치는 영향을 알아보았다. 1-Octanol의 농도가 증가할수록 beads의 형태는 구형으로부터 불규칙한 형태로 변화하였으며, 평균 beads의 크기는 증가하였다. 기공도와 기공 평균반지름 또한 증가하였다. PVP의 농도를 증가시킨 경우 beads의 평균반지름은 작아졌으나, 농도가 3% 이상인 경우 그 영향은 무시할 만하였다. 기공도는 약 25% 정도 증가하였으나, 평균반지름에서는 큰 변화를 관찰할 수 없었다. 전체 beads 형태에 대한 PVP의 영향은 크지 않았으나, bead 표면에서의 미세구밀도를 매우 낮추었다.

Poly(hydroxyethylmethacrylate)(polyHEMA) beads were prepared by suspension polymerization and the effects of 1-octanol and PVP(poly(N-vinyl-2- pyrrolidone) K-90) were investigated on the shape, size distribution, porosity and average pore radius of polyHEMM. As the concentration of 1-octanol increased, the shape became irregular and the average bead size centration. The effect on the whole shape was not significant but it maked the density of microsphere on the surface very lower.

Keywords:PolyHEMA Beads;Morphology;1-Octanol;PVP(poly(N-vinyl-2-pyrrolidone) K-90)

[References]

Hermanson GT, "Immobilized Affinity Ligand Techniques," Academic Press, Inc., San Diego (1992)
Turkova J, "Bioaffinity Chromatography," Elsevier, Amsterdam (1993)
Skely PJ, Tighe BJ, Polym. Commun., 20, 1051 (1979)
Piskin E, Int. J. Artif. Org., 9, 401 (1986)
Horak D, Svec F, Kalal J, Adamyan A, Skuba N, Titova M, Dan V, Varava B, Trostenyuk N, Vorankova O, Gumargalieava K, Timochina V, Biomaterials, 9, 367 (1988)
Robert CCR, Buri PA, Peppas NA, J. Control. Release, 5, 151 (1987)
Scranton AB, Mikos AG, Scranton LC, Peppas NA, J. Appl. Polym. Sci., 40, 997 (1990)
Mueller KF, Heiber SJ, J. Appl. Polym. Sci., 27, 4043 (1982)
Mueller KF, Heiber SJ, Plankl WL, U.S. Patent, 4,224,427 (1980)
Jayakrishnan A, Thanoo BC, J. Biomed. Mater. Res., 24, 913 (1990)
Lee HJ, Kim JH, Chem. Ind. Technol., 14(6), 529 (1996)
Tsung M, Burgess DJ, J. Pharm. Sci., 86(5), 603 (1997)
Haaf F, Sanner A, Straub F, Polym. J., 17(1), 143 (1985)
Kricheldorf HR, "Handbook of Polymer Synthesis Part A," Marchel Dekker, Inc., New York (1991)
Yao H, Takahara S, Mazuda H, Kozeki T, Hayasi T, Jpn. J. Appl. Phys., 35, 4633 (1996)
Lafreneire LY, Talbot FDF, Ind. Eng. Chem. Res., 26, 2385 (1987)
Hwang JR, Sefton MV, J. Membr. Sci., 108(3), 257 (1995)
Horak D, Lednicky F, Rehak V, Svec F, J. Appl. Polym. Sci., 49, 2041 (1993)
Scholtz E, Fresenius Z, Anal. Chem., 312, 460 (1982)

[Referenced By]

[1] Hermanson GT, "Immobilized Affinity Ligand Techniques," Academic Press, Inc., San Diego (1992)

[2] Turkova J, "Bioaffinity Chromatography," Elsevier, Amsterdam (1993)

[3] Skely PJ, Tighe BJ, Polym. Commun., 20, 1051 (1979)

[4] Piskin E, Int. J. Artif. Org., 9, 401 (1986)

[5] Horak D, Svec F, Kalal J, Adamyan A, Skuba N, Titova M, Dan V, Varava B, Trostenyuk N, Vorankova O, Gumargalieava K, Timochina V, Biomaterials, 9, 367 (1988)

[6] Robert CCR, Buri PA, Peppas NA, J. Control. Release, 5, 151 (1987)

[7] Scranton AB, Mikos AG, Scranton LC, Peppas NA, J. Appl. Polym. Sci., 40, 997 (1990)

[8] Mueller KF, Heiber SJ, J. Appl. Polym. Sci., 27, 4043 (1982)

[9] Mueller KF, Heiber SJ, Plankl WL, U.S. Patent, 4,224,427 (1980)

[10] Jayakrishnan A, Thanoo BC, J. Biomed. Mater. Res., 24, 913 (1990)

[11] Lee HJ, Kim JH, Chem. Ind. Technol., 14(6), 529 (1996)

[12] Tsung M, Burgess DJ, J. Pharm. Sci., 86(5), 603 (1997)

[13] Haaf F, Sanner A, Straub F, Polym. J., 17(1), 143 (1985)

[14] Kricheldorf HR, "Handbook of Polymer Synthesis Part A," Marchel Dekker, Inc., New York (1991)

[15] Yao H, Takahara S, Mazuda H, Kozeki T, Hayasi T, Jpn. J. Appl. Phys., 35, 4633 (1996)

[16] Lafreneire LY, Talbot FDF, Ind. Eng. Chem. Res., 26, 2385 (1987)

[17] Hwang JR, Sefton MV, J. Membr. Sci., 108(3), 257 (1995)

[18] Horak D, Lednicky F, Rehak V, Svec F, J. Appl. Polym. Sci., 49, 2041 (1993)

[19] Scholtz E, Fresenius Z, Anal. Chem., 312, 460 (1982)