Sulfonated Poly(ethylene glycol) Containing Methacrylate Copolymer Surfaces; Preparation, Characterization and In Vitro Biocompatibility

Ki Dong Park; Hyung Dal Park; Hee Jung Lee; Young Ha Kim; Tooru Ooya; Nobuhiko Yui

Macromolecular Research, Vol.12, No.4, 342-351, August, 2004

Ki Dong Park^†, Hyung Dal Park, Hee Jung Lee¹, Young Ha Kim¹, Tooru Ooya², and Nobuhiko Yui²

Department of Molecular Science and Technology, Ajou University, Suwon 442-749, Korea
¹Biomaterials Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea
²School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Tatsunokuchi,Ishikawa 923-1292, Japan

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Poly(ethylene glycol) (PEG1K) and sulfonated PEG (PEG1K-SO₃) methacrylate (MA) copolymers have been prepared and characterized. The structures of the synthesized copolymers were confirmed by ¹H and ¹³C NMR spectroscopy and elemental analysis. The bulk characteristics of the copolymers were evaluated by viscosity and thermal analysis. The surface properties of the copolymers were investigated using dynamic contact angle measurements and electron spectroscopy for chemical analysis. The hydrophilicity of the surfaces modified with PEG1KMA or PEG1K-SO₃MA increased, possibly as a result of the orientation of the hydrophilic PEG1KMA/PEG1K-SO₃MA chains into the water phase. Platelets adhered less to the surfaces of the copolymers than they did to a polyurethane control. In addition, adhesion of platelets to the copolymer surfaces decreased upon increasing the chain density of PEG1KMA and sulfonated PEG1KMA in the copolymers. Both bacterial adhesion and protein adsorption were significantly reduced on the copolymer surfaces and their levels differ depending on the kind of surface or media.

Keywords:sulfonated-PEG methacrylate copolymers;platelet adhesion;protein adsorption;bacterial adhesion.

[References]

Han DK, Park KD, Ryu GH, Kim YH, J. Biomater. Sci.-Polym. Ed., 9, 163 (1998)
Kim YH, Park KD, Han DK, in Advances in Polymeric Biomaterial Science, T. Akaike et al., Eds., CMC Co., Tokyo, 53 (1997)
Lee JH, Kopeckova P, Kopecek J, Andrade JD, Biomaterials, 11, 455 (1990)
Lee JH, Jeong BJ, Lee HB, J. Biomed. Mater. Res., 34, 105 (1997)
Lee JH, Ju YM, Lee WK, Park KD, Kim YH, J. Biomed. Mater. Res., 40, 314 (1998)
Han DK, Ryu GH, Park KD, Jeong SY, Kim YH, Min BG, J. Biomater. Sci.-Polym. Ed., 4, 401 (1993)
Han DK, Park KD, Jeong SY, Kim YH, Kim UY, Min BG, J. Biomed. Mater. Res., 27, 1063 (1993)
Han DK, Lee KB, Park KD, Kim CS, Jeong SY, Kim YH, Kim HM, Min BG, ASAIO J., 39, 537 (1993)
Park KD, Yun JY, Han DK, Jeong SY, Kim YH, ASAIO J., 40, 377 (1994)
Han DK, Park KD, Jeong SY, Kim YH, Lee NY, Cho HI, Min BG, Biomaterials, 16, 467 (1995)
Park KD, Suzuki K, Lee WK, Lee JE, Kim YH, Sakurai Y, Okano T, ASAIO J., 42, 876 (1996)
Lee HJ, Park KD, Han DK, Kim YH, Cho I, Polym.(Korea), 21(6), 1045 (1997)
Park KD, Lee WK, Yun JY, Han DK, Kim YH, Kim HM, Kim KT, Biomaterials, 18, 47 (1997)
Kim YH, Han DK, Park KD, Kim SH, Macromol. Symp., 118, 565 (1997)
Han DK, Park KD, Hubbell JA, Kim YH, J. Biomater. Sci.-Polym. Ed., 9, 667 (1998)
Park KD, Kim YS, Han DK, Kim YH, Bae EH, Suh H, Choi KS, Biomaterials, 19, 851 (1998)
Lee HJ, Park KD, Park HD, Lee WK, Han DK, Kim SH, Kim YH, J. Colloid and Surfaces B : Biointerfaces, 18, 355 (2000)
Wesslen B, Kober M, Freij-Larsson C, Ljungh A, Paulsson M, Biomaterials, 15, 278 (1994)
Rabinow BE, Ding YS, Qin C, McHalsky ML, Schneider JH, Ashline KA, Shelbourn TL, Albrecht RM, J. Biomater. Sci.-Polym. Ed., 6, 91 (1994)
Dilks A, Dawkins JV, Eds., in Developments in Polymer Characterizations, Applied Science, London, England, 145 (1980)
Jeon SI, Lee JH, Andrade JD, De Gennes PG, J. Colloid Interface Sci., 142, 149 (1991)
Jeon SI, Andrade JD, J. Colloid Interface Sci., 142, 159 (1991)
Desai NP, Hossainy SFA, Hubbell JA, Biomaterials, 13, 417 (1992)
Sioshanisi P, Tobin EJ, Med. Plastics Biomaterials, April, 50 (1995)
Bridgett MJ, Davies MC, Denyer SP, Biomaterials, 13, 411 (1992)
Nagaoka S, Kawakami H, ASAIO J., 41, 365 (1995)
Schierholz Z, Jansen B, Steinhauser H, Peters G, Schumacher-Perdreau F, Pulverer G, New Polymeric Mater, 3, 61 (1991)
Woodyard LL, Bowersock TL, Turek JJ, McCabe GP, DeFord JA, J. Control. Release, 40, 23 (1996)

[Referenced By]

[Related Articles]

[1] Han DK, Park KD, Ryu GH, Kim YH, J. Biomater. Sci.-Polym. Ed., 9, 163 (1998)

[2] Kim YH, Park KD, Han DK, in Advances in Polymeric Biomaterial Science, T. Akaike et al., Eds., CMC Co., Tokyo, 53 (1997)

[3] Lee JH, Kopeckova P, Kopecek J, Andrade JD, Biomaterials, 11, 455 (1990)

[4] Lee JH, Jeong BJ, Lee HB, J. Biomed. Mater. Res., 34, 105 (1997)

[5] Lee JH, Ju YM, Lee WK, Park KD, Kim YH, J. Biomed. Mater. Res., 40, 314 (1998)

[6] Han DK, Ryu GH, Park KD, Jeong SY, Kim YH, Min BG, J. Biomater. Sci.-Polym. Ed., 4, 401 (1993)

[7] Han DK, Park KD, Jeong SY, Kim YH, Kim UY, Min BG, J. Biomed. Mater. Res., 27, 1063 (1993)

[8] Han DK, Lee KB, Park KD, Kim CS, Jeong SY, Kim YH, Kim HM, Min BG, ASAIO J., 39, 537 (1993)

[9] Park KD, Yun JY, Han DK, Jeong SY, Kim YH, ASAIO J., 40, 377 (1994)

[10] Han DK, Park KD, Jeong SY, Kim YH, Lee NY, Cho HI, Min BG, Biomaterials, 16, 467 (1995)

[11] Park KD, Suzuki K, Lee WK, Lee JE, Kim YH, Sakurai Y, Okano T, ASAIO J., 42, 876 (1996)

[12] Lee HJ, Park KD, Han DK, Kim YH, Cho I, Polym.(Korea), 21(6), 1045 (1997)

[13] Park KD, Lee WK, Yun JY, Han DK, Kim YH, Kim HM, Kim KT, Biomaterials, 18, 47 (1997)

[14] Kim YH, Han DK, Park KD, Kim SH, Macromol. Symp., 118, 565 (1997)

[15] Han DK, Park KD, Hubbell JA, Kim YH, J. Biomater. Sci.-Polym. Ed., 9, 667 (1998)

[16] Park KD, Kim YS, Han DK, Kim YH, Bae EH, Suh H, Choi KS, Biomaterials, 19, 851 (1998)

[17] Lee HJ, Park KD, Park HD, Lee WK, Han DK, Kim SH, Kim YH, J. Colloid and Surfaces B : Biointerfaces, 18, 355 (2000)

[18] Wesslen B, Kober M, Freij-Larsson C, Ljungh A, Paulsson M, Biomaterials, 15, 278 (1994)

[19] Rabinow BE, Ding YS, Qin C, McHalsky ML, Schneider JH, Ashline KA, Shelbourn TL, Albrecht RM, J. Biomater. Sci.-Polym. Ed., 6, 91 (1994)

[20] Dilks A, Dawkins JV, Eds., in Developments in Polymer Characterizations, Applied Science, London, England, 145 (1980)

[21] Jeon SI, Lee JH, Andrade JD, De Gennes PG, J. Colloid Interface Sci., 142, 149 (1991)

[22] Jeon SI, Andrade JD, J. Colloid Interface Sci., 142, 159 (1991)

[23] Desai NP, Hossainy SFA, Hubbell JA, Biomaterials, 13, 417 (1992)

[24] Sioshanisi P, Tobin EJ, Med. Plastics Biomaterials, April, 50 (1995)

[25] Bridgett MJ, Davies MC, Denyer SP, Biomaterials, 13, 411 (1992)

[26] Nagaoka S, Kawakami H, ASAIO J., 41, 365 (1995)

[27] Schierholz Z, Jansen B, Steinhauser H, Peters G, Schumacher-Perdreau F, Pulverer G, New Polymeric Mater, 3, 61 (1991)

[28] Woodyard LL, Bowersock TL, Turek JJ, McCabe GP, DeFord JA, J. Control. Release, 40, 23 (1996)