화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.13, No.2, 147-151, April, 2005
Export Citation
Modulation of Poly( β-amino ester) pH-Sensitive Polymers by Molecular Weight Control
Min Sang Kim, Doo Sung Lee†, Eun-Kyung Choi1, Heon-Joo Park2, and Jin-Seok Kim3
  • Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Kyungki 440-746, Korea
  • 1Department of Radiation Oncology, University of Ulsan, Ulsan 680-749, Korea
  • 2Department of Microbiology, College of Medicine, Inha University, Incheon 402-751, Korea
  • 3College of Pharmacy, Sookmyung Women’s University, Seoul 140-742, Korea
E-mail:
The main objective of this study was to modulate pH-sensitive polymers (poly( β-amino esters)) by controlling their molecular weight during their synthesis. These pH-sensitive and biodegradable polymers were synthesized by Michael-type step polymerization. 1,4-Butane diol diacrylate was used as the unsaturated carbonyl compound and piperazine as the nucleophilic compound. Various molecular weight polymers were obtained by varying the mol ratio of piperazine/1,4-butane diol diacrylate. The synthesized polymers were characterized by 1HNMR and their molecular weights were measured by gel permeation chromatography(GPC). The dependence of the molecular weight on the mol ratio was evaluated by the titration method. Also, the pH dependent turbidity of the polymers was determined by UV-Vis spectrophotometry. This pH dependent property of the polymers could be very useful for preparing drug carriers that are sensitive to pH.
Keywords:pH-sensitive polymer;pKb;molecular weight control
  1. Sato N, Okada T, Horiuchi H, Murakami N, Takakashi J, nawata M, Ota H, Nozaki K, Takaoka K, Nat. Biotechnol., 19, 332 (2001) 
  2. Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM, Chem. Rev., 99(11), 3181 (1999) 
  3. Ravikumar MNV, Kumar N, Drug Dev. Ind. Pharm., 27, 1 (2001) 
  4. Park SY, Bae YH, Macromol. Rapid Commun., 20, 269 (1999) 
  5. Lee ES, Shin HJ, Na K, Bae YH, J. Control. Release, 90, 363 (2003) 
  6. Lynn DM, Langer R, J. Am. Chem. Soc., 122(44), 10761 (2000) 
  7. Lyun DM, Amiji MM, Langer R, Angew. Chem.-Int. Edit., 40, 1707 (2001) 
  8. Potineni A, Lyun DM, Langer R, Amiji MM, J. Control. Release, 86, 223 (2003) 
  9. Warshawsky A, Kahana N, Kampel V, Rogachev I, Meinhardt E, Kautzmann R, Cortina JL, Sampaio C, Macromol. Mater. Eng., 283, 103 (2000)