초임계 이산화탄소 내에서 아세트아미노펜 미세입자 제조

최성우; 오경실; 김화용; Sungwoo Choi; Kyungshil Oh; Hwayong Kim

Clean Technology, Vol.10, No.4, 215-220, December, 2004

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초임계 이산화탄소 내에서 아세트아미노펜 미세입자 제조

Precipitation of Acetaminophen in Supercritical Carbon Dioxide

최성우, 오경실, 김화용 ^†

서울대학교 응용화학부 열물성연구실, 서울특별시 관악구 신림2동 산 56-1번지

Sungwoo Choi, Kyungshil Oh, and Hwayong Kim^†

School of Chemical Engineering, Seoul National University, San 56-1, Shilim-dong, Kwanak-ku, Seoul, 151-744,Korea

E-mail:

초록

본 연구에서는 초임계 이산화탄소를 역용매로 이용하고, 에탄올을 용매로 하여 마이크로 사이즈의 아세트 아미노펜 입자를 제조하였다. 아세트아미노펜/에탄올 용액과 초임계 이산화탄소를 침전조에 주입할 때 이중 노즐을 사용하였다. 반응 온도와 압력, CO2의 유량과 아세트아미노펜/에탄올 용액의 유량의 변화가 입자의 크기와 형상에 미치는 영향에 대해 살펴보았다. 제조된 입자의 크기와 형상은 SEM으로 분석하였다.

Micronized acetaminophen was precipitated from ethanol solution using supercritical CO2 as antisolvent. A coaxial nozzle was used to introduce the supercritical CO2 and the acetaminophen/ethanol solution. The effects of pressure, temperature, CO2 flow rate and solvent flow rate were studied in the constant pressure and temperature condition. The particle size and morphology were influenced by the variations of precipitation condition. The particle size and morphology were analyzed with scanning electron microscopy.

[References]

Gallagher PM, Coffey MP, Krukonis VJ, Hillstorm WW, J. Supercrit. Fluids, 5, 130 (1992)
Bleich J, M.ller BW, Wabmus W, Int. J. Pharm., 97, 111 (1993)
Hanna M, York P, Patent WO 95/01221
Wubbolts FE, Bruinsma OSL, van Rosmalen GM, J. Cryst. Growth, 198, 767 (1999)
Shekunov B, Hanna M, York P, J. Cryst. Growth, 198, 1345 (1999)
Bristow S, Shekunov T, Shekunov B, York P, J. Supercrit. Fluids, 21, 257 (2001)
Kalogiannis K, Lambrou C, Lee YW, Panayiotou C, ‘Paracetamol micronization by precipitation with the SAS/SEDS process: influence of process parameters’, Proceedings of the 6th International Symposium on Supercritical Fluids, Versailles, France (2003)
Jasuja A, Trans. Am. Soc. Mech. Eng., 103, 514 (1981)

[Referenced By]

[Related Articles]

[1] Gallagher PM, Coffey MP, Krukonis VJ, Hillstorm WW, J. Supercrit. Fluids, 5, 130 (1992)

[2] Bleich J, M.ller BW, Wabmus W, Int. J. Pharm., 97, 111 (1993)

[3] Hanna M, York P, Patent WO 95/01221

[4] Wubbolts FE, Bruinsma OSL, van Rosmalen GM, J. Cryst. Growth, 198, 767 (1999)

[5] Shekunov B, Hanna M, York P, J. Cryst. Growth, 198, 1345 (1999)

[6] Bristow S, Shekunov T, Shekunov B, York P, J. Supercrit. Fluids, 21, 257 (2001)

[7] Kalogiannis K, Lambrou C, Lee YW, Panayiotou C, ‘Paracetamol micronization by precipitation with the SAS/SEDS process: influence of process parameters’, Proceedings of the 6th International Symposium on Supercritical Fluids, Versailles, France (2003)

[8] Jasuja A, Trans. Am. Soc. Mech. Eng., 103, 514 (1981)