Journal of Molecular Catalysis A-Chemical, Vol.196, No.1-2, 13-20, 2003
Facile preparation of chiral P,N-hydrazone ligands and their Pd-catalyzed asymmetric allylic alkylations
Chiral hydrazone ligands 2 are easily accessible in good yields by nucleophilic phosphanylation of corresponding orthofluorobenzaldehyde SAMP hydrazone derivatives with KPPh2. Palladium-catalyzed asymmetric allylic alkylation of 1,3diphenyl-2-propenyl acetate (6) with a dimethyl malonate-BSA-LiOAc system has been successfully carried out in the presence of chiral hydrazone ligands 2g in high yields with high enantioselectivities. (C) 2002 Elsevier Science B.V. All rights reserved.