Journal of Molecular Catalysis A-Chemical, Vol.196, No.1-2, 21-25, 2003
Asymmetric palladium-catalyzed nucleophilic substitution of 1-(2-naphthyl)ethyl acetate by dimethyl malonate anion
The asymmetric palladium-catalyzed nucleophilic substitution of 1-(2-naphthyl)ethyl acetate (1) by dimethyl malonate anion was realized and led to dimethyl 2-[1-(2-naphthyl)ethyl]propanedioate (2) with up to 74% ee. The analysis of the course of the reaction gave some information on the behaviour of the intermediate complexes. (C) 2002 Elsevier Science B.V. All rights reserved.
Keywords:palladium;asymmetric catalysis;benzylic nucleophilic substitution;C-C bond formation;elimination