Korean Journal of Chemical Engineering, Vol.25, No.3, 581-584, May, 2008
Micronization of arbutine using supercritical anti-solvent
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Arbutine has been used as skin whitening agent in cosmetics and pharmaceuticals. The objective of this study was to precipitate arbutine micro-particles using a supercritical anti-solvent. Ethanol and supercritical CO2 were used as solvent and anti-solvent, respectively, under various conditions. The effects of pressure, temperature and solution flow rate on the particles were studied. The particle size and morphology were analyzed by field emission scanning electron microscopy.
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