화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Clean Technology, Vol.14, No.4, 242-247, December, 2008
Export Citation
초임계 반용매법을 이용한 폴리비닐피롤리돈 미세입자의 제조
Preparation of Poly(N-vinyl-2-pyrrolidone) Microparticles Using Supercritical Anti-solvent
신문삼, 김화용†
  • 서울대학교 화학생물공학부, 151-744 서울시 관악구 신림동 산56-1
Moon Sam Shin, and Hwayong Kim†
  • School of Chemical and Biological Engineering, Seoul National University, San 56-1, Shinlim-dong, Gwanak-gu, Seoul 151-744, Korea
E-mail:
초록
화장품, 의약품, 전자소재 분야에서 생체적합, 생분해성 고분자로 널리 사용되는 폴리비닐피롤리돈(PVP)을 에어로젤 용매추출 방법에 의해 미세입자를 제조하였다. 용매로는 이 염화메탄올, 반용매로는 초임계 이산화탄소가 사용되었다. 온도, 압력, 이산화탄소 유량, 용액유량의 작업조건에 따라 0.184 - 0.249 μm 입자크기를 얻었고, 그 입자크기에 영향을 미치는 초기구형 입자크기와의 상관관계를 규명하였다.
Poly(N-vinyl-2-pyrrolidone) (PVP) has been used as biocompatible and biodegradable polymer in cosmetics, pharmaceuticals and electronics. Micro-particles of PVP were produced using an aerosol solvent extraction system (ASES). Dichloromethane (DCM) and supercritical carbon dioxide were used as solvent and antisolvent, respectively. The mean diameter of the obtained polymer particles ranged from 0.184 to 0.249 μm. The relationship between particle size and initial drop size was also considered.
Keywords:폴리비닐피롤리돈;반용매;미세입자;초임계 유체;고분자;Poly(N-vinyl-2-pyrrolidone);Anti-solvent;Microparticles;Supercritical fluids;Polymer
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