Chemistry Letters, Vol.37, No.4, 470-471, 2008
Synthesis and stereochemical assignment of angucycline antibiotic, PD-116740
The first total synthesis and absolute structure assignment of PD-116740 (2) was achieved by exploiting two key steps: 1) a thermal ring expansion of a benzocyclobutene derivative, and 2) pinacol cyclization of biaryl dialdehyde.