화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.28, No.3, 633-642, March, 2011
DOI10.1007/s11814-010-0533-8  Export Citation
Microfluidic extraction using two phase laminar flow for chemical and biological applications
Yun Suk Huh, Sang Jun Jeon1, Eun Zoo Lee2, Ho Seok Park3, and Won Hi Hong2, †
  • Division of Materials Science, Korea Basic Science Institute, Daejeon 305-333, Korea
  • 1Biochemical team, GSCaltex R&D Center, Daejeon 305-380, Korea
  • 2Department of Chemical and Biomolecular Engineering (BK21 program), KAIST, 335 Gwahak-ro, Yuseong-gu, Daejeon 305-701, Korea
  • 3Department of Chemical Engineering, College of Engineering, Kyung Hee University, 1 Seochon-dong, Giheung-gu, Yongin-si, Gyeonggi-do 446-701, Korea
E-mail:
We review the state of the art in microfluidic separation technique based two-phase laminar flow with an application focus on chemical and biological sample. As we describe herein, two-phase laminar flow in the microfluidic extraction has several biological and engineering advantages over other methods including high reproducibility, biocompatibility, and selectivity. We review advances in applications of two-phase laminar flow and examine key parameters such as flow rate, phase composition, and surface charge property, how these can affect extract performance with the technology including microfluidic separation system. A special technology focus is given to emerging novel integrative microfluidic extraction, which aims to merge aqueous phase laminar flow and electric field technologies into simple packages. We conclude with a brief discussion of some of the emerging challenges in the field and some of the approaches that are likely to enhance their application.
Keywords:Microfluidic Device;Two-phase System;Separation;Extraction;Protein;Cell
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