On-eye movement of commercial soft contact lenses (SCL) is crucial to the health of the cornea Comfort and safety of a SCL lens depends on both the water content of and the water flux through the lens membrane To acquire SCL water-permeability data, a newly designed fan-evaporation cell (FEC) is constructed. The fan-evaporation cell uses a more simple design compared to the previously used vacuum-evaporation cell for flat membranes [16] The new cell accommodates both commercial SCLs and flat-sheet membranes. After correcting for membrane thickness, measured water fluxes in the FEC agree with those obtained in the vacuum-evaporation cell (VEC) validating the new FEC. Ambient-temperature (23 5 degrees C) and on-eye (35 degrees C) gradient-driven water fluxes are reported for 10 commercial SCLs including both HEMA and silicone-hydrogel materials For relative humidities less than about 75%, effective Fickian diffusivities of water in the hydrogels are about 3 x 10(-7) cm(2)/s, essentially independent of lens material, saturated water content, and temperature. The effect of salt, mucin, and lysozyme on water-transport rates is minimal through Biomedics (R) 38, PureVision (TM), and Focus (R) DAILIES (R) lenses However, lysozyme significantly reduces water flux through Acuvue 2 lenses. (C) 2010 Elsevier B.V All rights reserved.