| 초록 |
The synthetic procedures of polyacryloylsulfadiazine were searched by DCCand Acid Chloride methods. Polymeric drug was synthesized by Acid Chloride methodin high yield but DCC method in low yield. The antimicrobial activities ofpolymeric drug was investigated in terms of minimum inhibitory concentrations bythe common twofold dilution technique. Polymeric drug revealed an excellentantimicrobial activity against Bacillus subtilis ATCC 6633, Staphyloccus aureus IFO12732, Micrococcus luteus ATCC 9341, Klebsiella pueumouiae KCTC 1560, and similarto Mycrobacterium phlei IFO 3158, Salmonella typhimurium KCTC 1925,Escherichia coli BE 1186, Escherichia coli AB 0111, Pseudomonas aeruginosaIFO 13130. Polymeric drug have no antimicrobial activity against Candidaalbicans IFO 1594.
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