| 초록 |
Dye-doped silica nanoparticles(SiNPs) could make uniform size and shape and easily control of various diameters. These dye-doped SiNPs have functionalized using HIV1-TAT peptides that can deliver cargos such as oligonucleotides and proteins across the plasma membrane into living cells. In this study, we prepared TAT-functionalized SiNPs conjugated Cy5 labeled oligonucleotides and TAT peptide for the purpose of improving intracellular delivery. Acknowledgments: This research was supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology (2009-0069113) , and by Nuclear R&D program through the Korea Science and Engineering Foundation (KOSEF) funded by the Ministry of Education, Science and Technology (MEST) of Korea (Grant No. M20706010003-08M0601-00310), and by the Ministry of Knowledge Economy(MKE) and Korea Industrial Technology Foundation (KOTEF) through the Human Resource Training Project for Strategic Technology |
