Liquid-crystal-based biosensor for detecting Ca2+ in human saliva

Dong-Hyun Yeo; Soo-Young Park

Journal of Industrial and Engineering Chemistry, Vol.74, 193-198, June, 2019

DOI10.1016/j.jiec.2019.03.001 Export Citation

Liquid-crystal-based biosensor for detecting Ca2+ in human saliva

Dong-Hyun Yeo, and Soo-Young Park^†

Department of Polymer Science & Engineering, Polymeric Nanomaterials Laboratory, School of Applied Chemical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, 41566 Daegu, Republic of Korea

E-mail:

A transmission electron microscopy Cu grid cell filled with 4-cyano-40-pentylbiphenyl (5CB) was utilised for detecting Ca2+ ion after functionalising the water/5CB interface with poly(acrylic acid)-b-poly(4- cyanobiphenyl-40-oxyundecylacrylate) (PAA-b-LCP), wherein the LCP block was anchored to 5CB and the PAA block complexed with metal ions in water. The NaCl-treated cell exhibited homeotropic-to-planar orientational change when Ca2+ ions were injected into the aqueous phase owing to the replacement of the Na+ ions in the PAA chains with Ca2+ ions. The performance of the cell in detecting Ca2+ ions in human saliva was successfully verified to demonstrate the non-invasive detection.

Keywords:Liquid crystal;Biosensor;Calcium ion;Non-invasive;Saliva;Transmission electron microscopy copper;grid

[References]

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[1] Lee DY, Seo JM, Khan W, Kornfield JA, Kurji Z, Park SY, Soft Matter, 6, 1964 (2010)

[2] Kinsinger ML, Sun B, Abbott NL, Lynn DM, Adv. Mater., 19(23), 4208 (2007)

[3] Khan M, Park SY, Biosens. Bioelectron., 68, 404 (2015)

[4] Munir S, Kang IK, Park SY, Trends Anal. Chem., 83, 80 (2016)

[5] Munir S, Khan M, Park SY, Sens Actuators B Chem., 220, 508 (2015)

[6] Omer M, Park SY, Anal. Bioanal. Chem., 406, 5369 (2014)

[7] Brake JM, Mezera AD, Abbott NL, Langmuir, 19(16), 6436 (2003)

[8] Lockwood N, Gupta J, Abbott N, Surf. Sci. Rep., 63, 255 (2008)

[9] Brake JM, Mezera AD, Abbott NL, Langmuir, 19(21), 8629 (2003)

[10] Khan W, Park SY, Lab Chip, 12, 4553 (2012)

[11] Omer M, Khan M, Kim YK, Lee JH, Kang IK, Park SY, Colloids Surf. B: Biointerfaces, 121, 400 (2014)

[12] Zhulina EB, Birshtein TM, Borisov OV, Macromolecules, 28(5), 1491 (1995)

[13] Lego B, Skene WG, Giasson S, Macromolecules, 43(9), 4384 (2010)

[14] Carlton RJ, Gupta JK, Swift CL, Abbott NL, Langmuir, 28(1), 31 (2012)

[15] Nap RJ, Szleifer I, J. Chem. Phys., 149, 163309 (2018)

[16] Kriwet B, Kissel T, Int. J. Pharm., 127, 135 (1996)

[17] Ooya T, Eguchi M, Ozaki A, Yui N, Int. J. Pharm., 242, 47 (2002)

[18] Beto JA, Clin. Nutr. Res., 4, 1 (2015)

[19] Becerra-Tomas N, Estruch R, Bullo M, Casas R, Diaz-Lopez A, Basora J, Fito M, Serra-Majem L, Salas-Salvado J, Diabetes Care, 37, 3084 (2014)

[20] Kambalyal P, Kambalyal P, Hungund S, J. Int. Soc. Prev. Community Dent., 5, A68 (2015)

[21] Li GJ, Zhang LL, Lu L, Wu P, Zheng W, J. Occup. Environ. Med., 46, 241 (2004)

[22] Watanabe K, Tanaka T, Shigemi T, Saeki K, Fujita Y, Morikawa K, Nakashima H, Takahashi S, Watanabe S, Maki K, J. Trace Elem. Med. Biol., 25, 143 (2011)

[23] Takahashi S, Watanabe K, Maki, J. Trace Elem. Med. Biol., 25, 143 (2011)

[24] Watanabe K, Tanaka T, Shigemi T, Hayashida Y, Maki K, J. Trace Elem. Med. Biol., 23, 93 (2009)

[25] Chauncey HH, Lionetti F, Winer RA, Lisanti VF, J. Dent. Res., 33, 321 (1954)

[26] Humphrey SP, Williamson RT, J. Prosthet. Dent., 85, 162 (2001)

[27] Asif MH, Nur O, Willander M, Danielsson B, Biosens. Bioelectron., 24, 3379 (2009)

[28] Ankireddy SR, Kim J, Sens. Actuators B-Chem., 255, 3425 (2018)

[29] Kim S, Park JW, Kim D, Kim D, Lee IH, Jon S, Angew. Chem.-Int. Edit., 48, 4138 (2009)

[30] Ji HF, Thundat T, Biosens. Bioelectron., 17, 337 (2002)