화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.55, 21-34, November, 2017
DOI10.1016/j.jiec.2017.06.050  Export Citation
Advances in nanomicelles for sustained drug delivery
Najmeh Amirmahani1, 2, Nosrat O. Mahmoodi3, 1, †, Mohsen Mohammadi Galangash4, and Atefeh Ghavidast3, 4
  • 1Department of Chemistry, University Campus 2, University of Guilan, P.O. Box 41335-1914, Rasht, Iran
  • 2Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran
  • 3Department of Chemistry, Faculty of Science, University of Guilan, P.O. Box 41335-1914, Rasht, Iran
  • 4Department of Environmental Science, Faculty of Natural Resources, University of Guilan, Sowmeh Sara 1144, Guilan, Iran
E-mail:
The efficient direct access of therapeutic molecules to the target tissues is still a major obstacle in developing useful therapeutic interventions. Over the past decades, polymeric micelles are interesting nanocarries for drug delivery systems due to small size (10.100 nm), low toxicity, capacity to solubilize lipophilic drugs in core and high drug loading. Here, the design of various nanomicelles such as amphiphilic dendrimer, boronate ester linked, X-shaped four-armed gemini-like, amphiphilic based vitamin E, styrene-maleic acid, diselenide linkages, oleic acid and natural polymeric inulin and vitamin E, siRNA and natural water soluble polysaccharides nanomicelles described and their efficacy discussed.
Keywords:Drug delivery;Nanomicelles;Nanocarriers;Cytotoxicity
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